{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:39:39Z","timestamp":1792651179627,"version":"4.5.0"},"reference-count":41,"publisher":"National Academy of Sciences","issue":"19","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,5,8]]},"abstract":"<jats:p>Emerging pathogens potentially undergo rapid evolution while expanding in population size and geographic range during the course of invasion, yet it is generally difficult to demonstrate how these processes interact. Our analysis of a 30-yr data set covering a large-scale rabies virus outbreak among North American raccoons reveals the long lasting effect of the initial infection wave in determining how viral populations are genetically structured in space. We further find that coalescent-based estimates derived from the genetic data yielded an amazingly accurate reconstruction of the known spatial and demographic dynamics of the virus over time. Our study demonstrates the combined evolutionary and population dynamic processes characterizing the spread of pathogen after its introduction into a fully susceptible host population. Furthermore, the results provide important insights regarding the spatial scale of rabies persistence and validate the use of coalescent approaches for uncovering even relatively complex population histories. Such approaches will be of increasing relevance for understanding the epidemiology of emerging zoonotic diseases in a landscape context.<\/jats:p>","DOI":"10.1073\/pnas.0700741104","type":"journal-article","created":{"date-parts":[[2007,4,30]],"date-time":"2007-04-30T21:19:10Z","timestamp":1177967950000},"page":"7993-7998","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":214,"title":["A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus"],"prefix":"10.1073","volume":"104","author":[{"given":"Roman","family":"Biek","sequence":"first","affiliation":[{"name":"Department of Biology and Center for Disease Ecology, Emory University, 1510 Clifton Road, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Caroline","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Biology and Center for Disease Ecology, Emory University, 1510 Clifton Road, Atlanta, GA 30322;"},{"name":"Rabies Section, Centers for Disease Control and Prevention, 1600 Clifton Road, Mail-stop G33, Atlanta, GA 30333; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance A.","family":"Waller","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Rupprecht","sequence":"additional","affiliation":[{"name":"Rabies Section, Centers for Disease Control and Prevention, 1600 Clifton Road, Mail-stop G33, Atlanta, GA 30333; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"Real","sequence":"additional","affiliation":[{"name":"Department of Biology and Center for Disease Ecology, Emory University, 1510 Clifton Road, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2007,5,8]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5452.443"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2656.1998.00176.x"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0301.970110"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500057102"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-294X.2003.02051.x"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1121360"},{"key":"e_1_3_4_7_2","first-page":"1","volume":"931","year":"2005","unstructured":"WHO Tech Rep Ser 931, 1\u201388 (2005).","journal-title":"WHO Tech Rep Ser"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1006\/smvy.1994.1016"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.240326697"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.042400799"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/153036602321131878"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jhered\/esi031"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2003.2559"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2005.07.009"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.1271"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/15303660160025895"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308064100"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msj057"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198548522.001.0001","volume-title":"Biological Invasions: Theory and Practice","author":"Shigesada N","year":"1997","unstructured":"N Shigesada, K Kawasaki Biological Invasions: Theory and Practice (Oxford Univ Press, Oxford, 1997)."},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-39.4.869"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1139\/z98-042"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2005.03.012"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1006\/jtbi.1999.1064"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(95)00197-9"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05177"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.2307\/j.ctv1nzfgj7"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(95)01907-3"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1096-0031.1994.tb00181.x"},{"key":"e_1_3_4_29_2","unstructured":"DL Swofford Paup*4.0b10 (Sinauer Associates Sunderland MA 2003)."},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/14.9.817"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msj021"},{"key":"e_1_3_4_32_2","unstructured":"AJ Drummond A Rambaut BEAST v1.4 http:\/\/evolve.zoo.ox.ac.uk\/beast\/. (2003)."},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5347(03)00216-7"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/16.4.395"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msi103"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040088"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1086\/286013"},{"key":"e_1_3_4_38_2","unstructured":"EP Martins COMPARE version 4.6 (Department of Biology Indiana University Bloomington IN http:\/\/compare.bio.indiana.edu\/. (2004)."},{"key":"e_1_3_4_39_2","first-page":"555","volume":"13","author":"Yang Z","year":"1997","unstructured":"Z Yang Comput Appl Biosci 13, 555\u2013556 (1997).","journal-title":"Comput Appl Biosci"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058321"},{"key":"e_1_3_4_41_2","volume-title":"Using ArcGIS Geostatistical Analysis","author":"Johnston K","year":"2001","unstructured":"K Johnston, JM Ver Hoef, K Krivoruchko, N Lucas Using ArcGIS Geostatistical Analysis (ESRI, Redlands, CA, 2001)."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.0700741104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T20:07:30Z","timestamp":1707854850000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.0700741104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,8]]},"references-count":41,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2007,5,8]]}},"alternative-id":["10.1073\/pnas.0700741104"],"URL":"https:\/\/doi.org\/10.1073\/pnas.0700741104","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1090153.543369","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,8]]},"assertion":[{"value":"2007-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-05-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}