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Surprisingly, adoptive transfer of wild-type blood phagocytes rescued bacteria-specific T cell activation in CCR6-deficient mice, even when these cells were unable to participate in direct antigen presentation. These data demonstrate that T cell responses to a local bacterial infection follow a distinct tempo, largely determined by bacterial protein secretion, and that CCR6-mediated blood phagocyte recruitment to the site of infection is a critical step in the initiation of pathogen-specific immune responses in skin draining lymph nodes.<\/jats:p>","DOI":"10.1073\/pnas.0701363104","type":"journal-article","created":{"date-parts":[[2007,7,5]],"date-time":"2007-07-05T21:39:38Z","timestamp":1183671578000},"page":"12075-12080","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":40,"title":["CCR6-dependent recruitment of blood phagocytes is necessary for rapid CD4 T cell responses to local bacterial infection"],"prefix":"10.1073","volume":"104","author":[{"given":"Rajesh","family":"Ravindran","sequence":"first","affiliation":[{"name":"*Center for Infectious Diseases and Microbiology Translational Research, Department of Medicine, Division of 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