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Here, we describe the successful use of the promoter and untranslated regions from the\n                    <jats:italic>nanos<\/jats:italic>\n                    (\n                    <jats:italic>nos<\/jats:italic>\n                    ) orthologous gene of the yellow fever mosquito,\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    , to control sex- and tissue-specific expression of exogenously derived\n                    <jats:italic>mariner<\/jats:italic>\n                    MosI transposase-encoding DNA. Transgenic mosquitoes expressed transposase mRNA in abundance near or equal to the endogenous\n                    <jats:italic>nos<\/jats:italic>\n                    transcript and exclusively in the female germ cells. In addition, MosI mRNA was deposited in developing oocytes and localized and maintained at the posterior pole during early embryonic development. Importantly, four of five transgenic lines examined were capable of mobilizing a second MosI transgene into the mosquito genome, indicating that functional transposase was being produced. Thus, the\n                    <jats:italic>nos<\/jats:italic>\n                    control sequences show promise as part of a TE-based gene drive system.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0701515104","type":"journal-article","created":{"date-parts":[[2007,6,4]],"date-time":"2007-06-04T21:32:29Z","timestamp":1180992749000},"page":"9970-9975","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":63,"title":["<i>nanos<\/i>\n                    gene control DNA mediates developmentally regulated transposition in the yellow fever mosquito\n                    <i>Aedes aegypti<\/i>"],"prefix":"10.1073","volume":"104","author":[{"given":"Zach N.","family":"Adelman","sequence":"first","affiliation":[{"name":"Departments of *Molecular Biology and Biochemistry and"},{"name":"Department of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA 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