{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:21:28Z","timestamp":1789215688494,"version":"build-2803163510"},"reference-count":31,"publisher":"National Academy of Sciences","issue":"16","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,4,17]]},"abstract":"<jats:p>\n                    The spliceosome cycle consists of assembly, catalysis, and recycling phases. Recycling of postspliceosomal U4 and U6 small nuclear ribonucleoproteins (snRNPs) requires p110\/SART3, a general splicing factor. In this article, we report that the zebrafish\n                    <jats:italic>earl grey<\/jats:italic>\n                    (\n                    <jats:italic>egy<\/jats:italic>\n                    ) mutation maps in the\n                    <jats:italic>p110<\/jats:italic>\n                    gene and results in a phenotype characterized by thymus hypoplasia, other organ-specific defects, and death by 7 to 8 days postfertilization. U4\/U6 snRNPs were disrupted in\n                    <jats:italic>egy<\/jats:italic>\n                    mutant embryos, demonstrating the importance of p110 for U4\/U6 snRNP recycling\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Surprisingly, expression profiling of the\n                    <jats:italic>egy<\/jats:italic>\n                    mutant revealed an extensive network of coordinately up-regulated components of the spliceosome cycle, providing a mechanism compensating for the recycling defect. Together, our data demonstrate that a mutation in a general splicing factor can lead to distinct defects in organ development and cause disease.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0701919104","type":"journal-article","created":{"date-parts":[[2007,4,6]],"date-time":"2007-04-06T20:23:47Z","timestamp":1175891027000},"page":"6608-6613","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":67,"title":["Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110"],"prefix":"10.1073","volume":"104","author":[{"given":"Nikolaus S.","family":"Trede","sequence":"first","affiliation":[{"name":"*Department of Pediatrics, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Medenbach","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Justus-Liebig-University, D-35392 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