{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:04:25Z","timestamp":1792609465254,"version":"4.5.0"},"reference-count":35,"publisher":"National Academy of Sciences","issue":"25","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,6,19]]},"abstract":"\n At<\/jats:italic>\n Pep1, a 23-aa peptide encoded by\n Arabidopsis PROPEP1<\/jats:italic>\n , a member of a small, six-member gene family, activates expression of the defense gene\n PDF1.2<\/jats:italic>\n (encoding defensin) and its own precursor gene,\n PROPEP1<\/jats:italic>\n , through the jasmonate\/ethylene signaling pathway, mediated by a cell-surface receptor, PEPR1. Overexpression of two family members,\n PROPEP1<\/jats:italic>\n and\n PROPEP2<\/jats:italic>\n , enhances resistance of\n Arabidopsis<\/jats:italic>\n plants against the pathogen\n Pythium irregulare<\/jats:italic>\n , and\n PROPEP2<\/jats:italic>\n and\n PROPEP3<\/jats:italic>\n are expressed at highly elevated levels in\n Arabidopsis<\/jats:italic>\n in response to pathogen infections and to several pathogen-associated molecules (general elicitors). Here, we report that\n PDF1.2, PR-1<\/jats:italic>\n (pathogenesis protein), and\n PROPEP<\/jats:italic>\n genes were differentially expressed in the leaves of intact plants sprayed with methyl jasmonate and methyl salicylate and in excised leaves supplied through cut petioles with peptides derived from the C terminus of each of the encoded proteins. The expression of\n PDF1.2<\/jats:italic>\n and\n PR-1<\/jats:italic>\n elicited by the peptides was blocked in mutant plants deficient in the jasmonate\/ethylene and salicylate pathways, and in wild-type plants by treatment with diphenylene iodonium chloride, an inhibitor of hydrogen peroxide production.\n PROPEP1, PROPEP 2<\/jats:italic>\n , and\n PROPEP3<\/jats:italic>\n genes appear to have roles in a feedback loop that amplifies defense signaling pathways initiated by pathogens.\n <\/jats:p>","DOI":"10.1073\/pnas.0703343104","type":"journal-article","created":{"date-parts":[[2007,6,14]],"date-time":"2007-06-14T00:03:19Z","timestamp":1181779399000},"page":"10732-10736","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":216,"title":["Endogenous peptide defense signals in\n Arabidopsis<\/i>\n differentially amplify signaling for the innate immune response"],"prefix":"10.1073","volume":"104","author":[{"given":"Alisa","family":"Huffaker","sequence":"first","affiliation":[{"name":"Institute of Biological Chemistry, Washington State University, Pullman, WA 99164-6340"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarence A.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Washington State University, Pullman, WA 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