{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:51:30Z","timestamp":1781103090283,"version":"3.54.1"},"reference-count":28,"publisher":"National Academy of Sciences","issue":"22","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,5,29]]},"abstract":"<jats:p>\n                    Severe forms of anemia in children in the developing countries may be characterized by different clinical manifestations at particular stages of development. Whether this reflects developmental changes in adaptation to anemia or other mechanisms is not clear. The pattern of adaptation to anemia has been assessed in 110 individuals with hemoglobin (Hb) E \u03b2-thalassemia, one of the commonest forms of inherited anemia in Asia. It has been found that age and Hb levels are independent variables with respect to erythropoietin response and that there is a decline in the latter at a similar degree of anemia during development. To determine whether this finding is applicable to anemia due to other causes, a similar study has been carried out on 279 children with severe anemia due to\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    malaria; the results were similar to those in the patients with thalassemia. These observations may have important implications both for the better understanding of the pathophysiology of profound anemia in early life and for its more logical and cost-effective management.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0703424104","type":"journal-article","created":{"date-parts":[[2007,5,18]],"date-time":"2007-05-18T13:04:29Z","timestamp":1179493469000},"page":"9440-9444","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":50,"title":["Age-related changes in adaptation to severe anemia in childhood in developing countries"],"prefix":"10.1073","volume":"104","author":[{"given":"Angela","family":"O'Donnell","sequence":"first","affiliation":[{"name":"*Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX 3 9DS, United Kingdom;"},{"name":"Papua New Guinea Institute of Medical Research, P.O. Box 60, Goroka, 441, Papua, New Guinea;"},{"name":"Clinical School, University of Wales, Swansea SA2 8PP, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Premawardhena","sequence":"additional","affiliation":[{"name":"University of Kelaniya, Colombo, Sri Lanka;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Arambepola","sequence":"additional","affiliation":[{"name":"National Thalassaemia Centre, District Hospital, Kurunegala, Sri Lanka;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J.","family":"Allen","sequence":"additional","affiliation":[{"name":"*Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX 3 9DS, United Kingdom;"},{"name":"Papua New Guinea Institute of Medical Research, P.O. 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