{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:21:31Z","timestamp":1791303691882,"version":"4.1.0"},"reference-count":28,"publisher":"National Academy of Sciences","issue":"36","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,9,4]]},"abstract":"<jats:p>\n                    Highly quantitative biomarkers of neurodegenerative disease remain an important need in the urgent quest for disease-modifying therapies. For Huntington's disease (HD), a genetic test is available (trait marker), but necessary state markers are still in development. In this report, we describe a large battery of transcriptomic tests explored as state biomarker candidates. In an attempt to exploit the known neuroinflammatory and transcriptional perturbations of disease, we measured relevant mRNAs in peripheral blood cells. The performance of these potential markers was weak overall, with only one mRNA, immediate early response 3 (IER3), showing a modest but significant increase of 32% in HD samples compared with controls. No statistically significant differences were found for any other mRNAs tested, including a panel of 12 RNA biomarkers identified in a previous report [Borovecki F, Lovrecic L, Zhou J, Jeong H, Then F, Rosas HD, Hersch SM, Hogarth P, Bouzou B, Jensen RV,\n                    <jats:italic>et al.<\/jats:italic>\n                    (2005)\n                    <jats:italic>Proc Natl Acad Sci USA<\/jats:italic>\n                    102:11023\u201311028]. The present results may nonetheless inform the future design and testing of HD biomarker strategies.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0703652104","type":"journal-article","created":{"date-parts":[[2007,8,27]],"date-time":"2007-08-27T20:40:28Z","timestamp":1188247228000},"page":"14424-14429","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":120,"title":["Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood"],"prefix":"10.1073","volume":"104","author":[{"given":"Heike","family":"Runne","sequence":"first","affiliation":[{"name":"*Laboratory of Functional Neurogenomics, Brain Mind Institute, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Kuhn","sequence":"additional","affiliation":[{"name":"*Laboratory of Functional Neurogenomics, Brain Mind Institute, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Wild","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wirahpati","family":"Pratyaksha","sequence":"additional","affiliation":[{"name":"National Center of Competence in Research (NCCR) Molecular Oncology, Swiss Institute of Experimental Cancer Research (ISREC) and Swiss Institute of Bioinformatics (SIB) CH-1066 Epalinges, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Kristiansen","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D.","family":"Isaacs","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"R\u00e9gulier","sequence":"additional","affiliation":[{"name":"*Laboratory of Functional Neurogenomics, Brain Mind Institute, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Delorenzi","sequence":"additional","affiliation":[{"name":"National Center of Competence in Research (NCCR) Molecular Oncology, Swiss Institute of Experimental Cancer Research (ISREC) and Swiss Institute of Bioinformatics (SIB) CH-1066 Epalinges, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Tabrizi","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom; 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