{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:53:17Z","timestamp":1791168797573,"version":"4.1.0"},"reference-count":30,"publisher":"National Academy of Sciences","issue":"34","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,8,21]]},"abstract":"<jats:p>\n                    Hibernation is a fascinating, yet enigmatic, physiological phenomenon during which body temperature and metabolism are reduced to save energy. During the harsh season, this strategy allows substantial energy saving by reducing body temperature and metabolism. Accordingly, biological processes are considerably slowed down and reduced to a minimum. However, the persistence of a temperature-compensated, functional biological clock in hibernating mammals has long been debated. Here, we show that the master circadian clock no longer displays 24-h molecular oscillations in hibernating European hamsters. The clock genes\n                    <jats:italic>Per1<\/jats:italic>\n                    ,\n                    <jats:italic>Per2<\/jats:italic>\n                    , and\n                    <jats:italic>Bmal1<\/jats:italic>\n                    and the clock-controlled gene\n                    <jats:italic>arginine vasopressin<\/jats:italic>\n                    were constantly expressed in the suprachiasmatic nucleus during deep torpor, as assessed by radioactive\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization. Finally, the melatonin rhythm-generating enzyme, arylalkylamine\n                    <jats:italic>N<\/jats:italic>\n                    -acetyltransferase, whose rhythmic expression in the pineal gland is controlled by the master circadian clock, no longer exhibits day\/night changes of expression but constantly elevated mRNA levels over 24 h. Overall, these data provide strong evidence that in the European hamster the molecular circadian clock is arrested during hibernation and stops delivering rhythmic output signals.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0704699104","type":"journal-article","created":{"date-parts":[[2007,8,21]],"date-time":"2007-08-21T13:23:44Z","timestamp":1187702624000},"page":"13816-13820","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":124,"title":["The circadian clock stops ticking during deep hibernation in the European hamster"],"prefix":"10.1073","volume":"104","author":[{"given":"Florent G.","family":"Revel","sequence":"first","affiliation":[{"name":"*D\u00e9partement de Neurobiologie des Rythmes, Institut des Neurosciences Cellulaires et Int\u00e9gratives, Unit\u00e9 Mixte de Recherche 7168\/LC2, Centre National de la Recherche Scientifique, Universit\u00e9 Louis Pasteur, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Herwig","sequence":"additional","affiliation":[{"name":"*D\u00e9partement de Neurobiologie des Rythmes, Institut des Neurosciences Cellulaires et Int\u00e9gratives, Unit\u00e9 Mixte de Recherche 7168\/LC2, Centre National de la Recherche Scientifique, Universit\u00e9 Louis Pasteur, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France; and"},{"name":"Institute of Zoology, University of Veterinary Medicine, B\u00fcnteweg 17, Building 218, 30559 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Garidou","sequence":"additional","affiliation":[{"name":"*D\u00e9partement de Neurobiologie des Rythmes, Institut des Neurosciences Cellulaires et Int\u00e9gratives, Unit\u00e9 Mixte de Recherche 7168\/LC2, Centre National de la Recherche Scientifique, Universit\u00e9 Louis Pasteur, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Dardente","sequence":"additional","affiliation":[{"name":"*D\u00e9partement de Neurobiologie des Rythmes, Institut des Neurosciences Cellulaires et Int\u00e9gratives, Unit\u00e9 Mixte de Recherche 7168\/LC2, Centre National de la Recherche Scientifique, Universit\u00e9 Louis Pasteur, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me S.","family":"Menet","sequence":"additional","affiliation":[{"name":"*D\u00e9partement de Neurobiologie des Rythmes, Institut des Neurosciences Cellulaires et Int\u00e9gratives, Unit\u00e9 Mixte de Recherche 7168\/LC2, Centre National de la Recherche Scientifique, Universit\u00e9 Louis Pasteur, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Masson-P\u00e9vet","sequence":"additional","affiliation":[{"name":"*D\u00e9partement de Neurobiologie des Rythmes, Institut des Neurosciences Cellulaires et Int\u00e9gratives, Unit\u00e9 Mixte de Recherche 7168\/LC2, Centre National de la Recherche Scientifique, Universit\u00e9 Louis Pasteur, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Simonneaux","sequence":"additional","affiliation":[{"name":"*D\u00e9partement de Neurobiologie des Rythmes, Institut des Neurosciences Cellulaires et Int\u00e9gratives, Unit\u00e9 Mixte de Recherche 7168\/LC2, Centre National de la Recherche Scientifique, Universit\u00e9 Louis Pasteur, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Saboureau","sequence":"additional","affiliation":[{"name":"*D\u00e9partement de Neurobiologie des Rythmes, Institut des Neurosciences Cellulaires et Int\u00e9gratives, Unit\u00e9 Mixte de Recherche 7168\/LC2, Centre National de la Recherche Scientifique, Universit\u00e9 Louis Pasteur, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France; 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