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Forty-nine 50- to 80-year-old normal subjects were examined who received clinical, neuropsychological, and 2-[\n                    <jats:sup>18<\/jats:sup>\n                    F]fluoro-2-deoxy-\n                    <jats:sc>d<\/jats:sc>\n                    -glucose\u2013positron emission tomography examinations, including 16 subjects with a maternal (FHm) and eight with a paternal (FHp) family history of AD and 25 with no family history (FH\n                    <jats:sup>\u2212<\/jats:sup>\n                    ). FH groups were comparable for demographic and neuropsychological measures. As compared with both FH\n                    <jats:sup>\u2212<\/jats:sup>\n                    and FHp groups, FHm subjects showed CMRglc reductions in the same regions as clinically affected AD patients, involving the posterior cingulate cortex\/precuneus, parietotemporal and frontal cortices, and medial temporal lobes (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05, corrected for multiple comparisons). These effects remained significant after accounting for possible risk factors for AD, including age, gender, education, apolipoprotein E genotype, and subjective memory complaints. No CMRglc differences were found between FHp and FH\n                    <jats:sup>\u2212<\/jats:sup>\n                    subjects. This study shows a relationship between reduced CMRglc in AD-vulnerable brain regions and a maternal family history of AD in cognitively normal individuals.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0705036104","type":"journal-article","created":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T21:19:01Z","timestamp":1195075141000},"page":"19067-19072","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":192,"title":["Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism"],"prefix":"10.1073","volume":"104","author":[{"given":"Lisa","family":"Mosconi","sequence":"first","affiliation":[{"name":"*Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslaw","family":"Brys","sequence":"additional","affiliation":[{"name":"*Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remigiusz","family":"Switalski","sequence":"additional","affiliation":[{"name":"*Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Mistur","sequence":"additional","affiliation":[{"name":"*Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Glodzik","sequence":"additional","affiliation":[{"name":"*Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Pirraglia","sequence":"additional","affiliation":[{"name":"*Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai","family":"Tsui","sequence":"additional","affiliation":[{"name":"*Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016; and"},{"name":"Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"De Santi","sequence":"additional","affiliation":[{"name":"*Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mony J.","family":"de Leon","sequence":"additional","affiliation":[{"name":"*Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016; and"},{"name":"Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2007,11,27]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550160069041"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.GIM.0000132679.92238.58"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.3.329"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.5.565"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00476-7"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-1762-7"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.1.185"},{"key":"e_1_3_4_8_2","first-page":"1778","volume":"47","author":"Mosconi L","year":"2006","unstructured":"L Mosconi, S Sorbi, MJ de Leon, Y Li, B Nacmias, V Bessi, WH Tsui, PS Myoung, M Fayyaz, P Caffarra, et al. 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