{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:47:45Z","timestamp":1781102865229,"version":"3.54.1"},"reference-count":41,"publisher":"National Academy of Sciences","issue":"29","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,7,17]]},"abstract":"<jats:p>\n                    Alloreactive B cells can contribute to graft rejection. Anti-CD154 treatment together with donor-specific transfusion (DST) results in the long-term survival of MHC-mismatched mouse heart grafts and inhibition of alloantibody production. To characterize the mechanism of B cell tolerance induced by the anti-CD154 and DST, we used 3-83Igi mice, on BALB\/c (H-2K\n                    <jats:sup>d<\/jats:sup>\n                    ) background, that express a B cell receptor that reacts with MHC class I antigens H-2K\n                    <jats:sup>b<\/jats:sup>\n                    . Transplanting C57BL\/6 (H-2K\n                    <jats:sup>b<\/jats:sup>\n                    ) hearts into 3-83Igi mice, followed by tolerance induction, resulted in the peripheral deletion of mature but not immature 3-83 B cells. The sustained deletion of mature alloreactive B cells required the presence of the allograft and can be explained by the absence of T cell help.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0705240104","type":"journal-article","created":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T20:54:44Z","timestamp":1183496084000},"page":"12093-12098","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":21,"title":["Peripheral deletion of mature alloreactive B cells induced by costimulation blockade"],"prefix":"10.1073","volume":"104","author":[{"given":"Yijin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Surgery, Section of Transplantation, University of Chicago, Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianli","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Transplantation, University of Chicago, Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jikun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Transplantation, University of Chicago, Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita S.","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Transplantation, University of Chicago, Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2007,7,17]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1702"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200103150-00013"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V123574"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000153298.48353.A4"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/350423a0"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.11.1649"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200103270-00007"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199707270-00026"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/74731"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200202150-00021"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000053756.90975.8E"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199908)29:08<2367::AID-IMMU2367>3.0.CO;2-3"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.1.512"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.11.1311"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1333"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.21.9560"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-02-0586"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-1229(95)90234-1"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.10.5352"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80395-7"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1076"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/354308a0"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/337562a0"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1256"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6656"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1126"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.4049\/jimmunol.161.6.2677","volume":"161","author":"Ait-Azzouzene D","year":"1998","unstructured":"D Ait-Azzouzene, MC Gendron, M Houdayer, A Langkopf, K Burki, D Nemazee, C Kanellopoulos-Langevin J Immunol 161, 2677\u20132683 (1998).","journal-title":"J Immunol"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod65.2.337"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.13171"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.5.2313"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.6.2129"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.4049\/jimmunol.156.8.2657","volume":"156","author":"Monroe JG","year":"1996","unstructured":"JG Monroe J Immunol 156, 2657\u20132660 (1996).","journal-title":"J Immunol"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.1.75"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.2.939"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041854"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.12.2005"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.2.321"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200422325"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4255"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4180"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/15260"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.0705240104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T13:31:52Z","timestamp":1708003912000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.0705240104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,17]]},"references-count":41,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2007,7,17]]}},"alternative-id":["10.1073\/pnas.0705240104"],"URL":"https:\/\/doi.org\/10.1073\/pnas.0705240104","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,17]]},"assertion":[{"value":"2006-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-07-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}