{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:44:48Z","timestamp":1792295088120,"version":"4.4.0"},"reference-count":24,"publisher":"National Academy of Sciences","issue":"2","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2008,1,15]]},"abstract":"<jats:p>\n                    We study ionic current fluctuations in solid-state nanopores over a wide frequency range and present a complete description of the noise characteristics. At low frequencies (\n                    <jats:italic>f<\/jats:italic>\n                    \u2272 100 Hz) we observe 1\/\n                    <jats:italic>f<\/jats:italic>\n                    -type of noise. We analyze this low-frequency noise at different salt concentrations and find that the noise power remarkably scales linearly with the inverse number of charge carriers, in agreement with Hooge's relation. We find a Hooge parameter \u03b1 = (1.1 \u00b1 0.1) \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    . In the high-frequency regime (\n                    <jats:italic>f<\/jats:italic>\n                    \u2273 1 kHz), we can model the increase in current power spectral density with frequency through a calculation of the Johnson noise. Finally, we use these results to compute the signal-to-noise ratio for DNA translocation for different salt concentrations and nanopore diameters, yielding the parameters for optimal detection efficiency.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0705349105","type":"journal-article","created":{"date-parts":[[2008,1,9]],"date-time":"2008-01-09T21:05:49Z","timestamp":1199912749000},"page":"417-421","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":361,"title":["Noise in solid-state nanopores"],"prefix":"10.1073","volume":"105","author":[{"given":"R. M. M.","family":"Smeets","sequence":"first","affiliation":[{"name":"*Kavli Institute of Nanoscience, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U. F.","family":"Keyser","sequence":"additional","affiliation":[{"name":"*Kavli Institute of Nanoscience, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands; and"},{"name":"Institut fur Experimentelle Physik 1, Universit\u00e4t Leipzig, Linn\u00e9strasse 5, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. H.","family":"Dekker","sequence":"additional","affiliation":[{"name":"*Kavli Institute of Nanoscience, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dekker","sequence":"additional","affiliation":[{"name":"*Kavli Institute of Nanoscience, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2008,1,15]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.13770"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/35084037"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2007.27"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl0494001"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.97.088101"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.70.2352"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(94)80929-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.105.3.385"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01753-1"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(02)75442-8"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(98)77945-7"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.152206799"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.85.202"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.89.158101"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl052107w"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-1229-9_5"},{"key":"e_1_3_3_17_2","volume-title":"The Axon CNS Guide to Electrophysiology and Biophysics Laboratory Techniques","author":"Sherman-Gold R","unstructured":"R Sherman-Gold The Axon CNS Guide to Electrophysiology and Biophysics Laboratory Techniques (Molecular Devices, Sunnyvale, CA, 1993\u20132006."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1109\/94.326654"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0375-9601(69)90076-0"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1088\/0034-4885\/44\/5\/001"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002329900245"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl070462b"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat941"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl052163x"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.0705349105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T16:09:50Z","timestamp":1649779790000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.0705349105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,15]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,1,15]]}},"alternative-id":["10.1073\/pnas.0705349105"],"URL":"https:\/\/doi.org\/10.1073\/pnas.0705349105","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,15]]},"assertion":[{"value":"2007-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-01-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}