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We observed increased SNO-Prx2 in human Parkinson's disease (PD) brains, and S-nitrosylation of Prx2 inhibited both its enzymatic activity and protective function from oxidative stress. Dopaminergic neurons, which are lost in PD, become particularly vulnerable. Thus, our data provide a direct link between nitrosative\/oxidative stress and neurodegenerative disorders such as PD.<\/jats:p>","DOI":"10.1073\/pnas.0705904104","type":"journal-article","created":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T21:19:01Z","timestamp":1195075141000},"page":"18742-18747","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":230,"title":["S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease"],"prefix":"10.1073","volume":"104","author":[{"given":"Jianguo","family":"Fang","sequence":"first","affiliation":[{"name":"*Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"*Center for Neuroscience, Aging, and Stem 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