{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:42:03Z","timestamp":1791128523423,"version":"4.1.0"},"reference-count":47,"publisher":"National Academy of Sciences","issue":"48","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,11,27]]},"abstract":"<jats:p>\n                    The structural phenotype of neural connections in the auditory brainstem is sculpted by spontaneous and stimulus-induced neural activities during development. However, functional and molecular mechanisms of spontaneous action potentials (SAPs) in the developing cochlea are unknown. Additionally, it is unclear how regenerating hair cells establish their neural ranking in the constellation of neurons in the brainstem. We have demonstrated that a transient Ca\n                    <jats:sup>2+<\/jats:sup>\n                    current produced by the Ca\n                    <jats:sub>v<\/jats:sub>\n                    3.1 channel is expressed early in development to initiate spontaneous Ca\n                    <jats:sup>2+<\/jats:sup>\n                    spikes. Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.3 currents, typical of mature hair cells, appeared later in development. Moreover, there is a surprising disappearance of the Ca\n                    <jats:sub>v<\/jats:sub>\n                    3.1 current that coincides with the attenuation of the transient Ca\n                    <jats:sup>2+<\/jats:sup>\n                    current as the electrical properties of hair cells transition to the mature phenotype. Remarkably, this process is recapitulated during hair-cell regeneration, suggesting that the transient expression of Ca\n                    <jats:sub>v<\/jats:sub>\n                    3.1 and the ensuing SAPs are signatures of hair cell development and regeneration.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0705927104","type":"journal-article","created":{"date-parts":[[2007,11,19]],"date-time":"2007-11-19T21:15:10Z","timestamp":1195506910000},"page":"19108-19113","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":46,"title":["Development and regeneration of hair cells share common functional features"],"prefix":"10.1073","volume":"104","author":[{"given":"Snezana","family":"Levic","sequence":"first","affiliation":[{"name":"*Department of Otolaryngology, Program in Communication Science, Center for Neuroscience, University of California, 1544 Newton Court, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Nie","sequence":"additional","affiliation":[{"name":"*Department of Otolaryngology, Program in Communication Science, Center for Neuroscience, University of California, 1544 Newton Court, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipika","family":"Tuteja","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, University of California, 2315 Stockton Boulevard, Sacramento, CA 95817; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Harvey","sequence":"additional","affiliation":[{"name":"Otology Laboratory, Department of Otolaryngology, University of South Florida, MDC83, 12901 Bruce B. 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