{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:04:40Z","timestamp":1790874280473,"version":"4.1.0"},"reference-count":33,"publisher":"National Academy of Sciences","issue":"39","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,9,25]]},"abstract":"<jats:p>\n                    Deregulation of the Myc pathway and deregulation of the Rb pathway are two of the most common abnormalities in human malignancies. Recent\n                    <jats:italic>in vitro<\/jats:italic>\n                    experiments suggest a complex cross-regulatory relationship between Myc and Rb that is mediated through the control of E2F. To evaluate the functional connection between Myc and E2Fs\n                    <jats:italic>in vivo<\/jats:italic>\n                    , we used a bitransgenic mouse model of Myc-induced T cell lymphomagenesis and analyzed tumor progression in mice deficient for\n                    <jats:italic>E2f1<\/jats:italic>\n                    ,\n                    <jats:italic>E2f2<\/jats:italic>\n                    , or\n                    <jats:italic>E2f3<\/jats:italic>\n                    . Whereas the targeted inactivation of\n                    <jats:italic>E2f1<\/jats:italic>\n                    or\n                    <jats:italic>E2f3<\/jats:italic>\n                    had no significant effect on tumor progression, loss of\n                    <jats:italic>E2f2<\/jats:italic>\n                    accelerated lymphomagenesis. Interestingly, loss of a single copy of\n                    <jats:italic>E2f2<\/jats:italic>\n                    also accelerated tumorigenesis, albeit to a lesser extent, suggesting a haploinsufficient function for this locus. The combined ablation of\n                    <jats:italic>E2f1<\/jats:italic>\n                    or\n                    <jats:italic>E2f3<\/jats:italic>\n                    , along with\n                    <jats:italic>E2f2<\/jats:italic>\n                    , did not further accelerate tumorigenesis. Myc-overexpressing T cells were more resistant to apoptosis in the absence of\n                    <jats:italic>E2f2<\/jats:italic>\n                    , and the reintroduction of E2F2 into these tumor cells resulted in an increase of apoptosis and inhibition of tumorigenesis. These results identify the\n                    <jats:italic>E2f2<\/jats:italic>\n                    locus as a tumor suppressor through its ability to modulate apoptosis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0706307104","type":"journal-article","created":{"date-parts":[[2007,9,19]],"date-time":"2007-09-19T21:04:22Z","timestamp":1190235862000},"page":"15400-15405","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":53,"title":["Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis"],"prefix":"10.1073","volume":"104","author":[{"given":"Rene","family":"Opavsky","sequence":"first","affiliation":[{"name":"*Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine and Public Health and"},{"name":"Department of Molecular Genetics, College of Biological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Yin","family":"Tsai","sequence":"additional","affiliation":[{"name":"*Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine and Public Health and"},{"name":"Department of Molecular Genetics, College of Biological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Guimond","sequence":"additional","affiliation":[{"name":"*Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine and Public Health and"},{"name":"Division of Hematology and Oncology, Department of Internal Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjulie","family":"Arora","sequence":"additional","affiliation":[{"name":"*Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine and Public Health and"},{"name":"Department of Molecular Genetics, College of Biological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Opavska","sequence":"additional","affiliation":[{"name":"*Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine and Public Health and"},{"name":"Department of Molecular Genetics, College of Biological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Becknell","sequence":"additional","affiliation":[{"name":"*Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine and Public Health and"},{"name":"Division of Hematology and Oncology, Department of Internal Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"*Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine and Public Health and"},{"name":"Department of Molecular Genetics, College of Biological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel A.","family":"Walton","sequence":"additional","affiliation":[{"name":"*Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine and Public Health and"},{"name":"Department of Molecular Genetics, College of Biological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Center for Biostatistics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad A.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Center for Biostatistics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natarajan","family":"Muthusamy","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean W.","family":"Felsher","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Medicine, Stanford University, CCSR 1105B, 269 Campus Drive, Stanford, CA 94305-5151"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Porcu","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Caligiuri","sequence":"additional","affiliation":[{"name":"*Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine and Public Health and"},{"name":"Division of Hematology and Oncology, Department of Internal Medicine, and"},{"name":"The Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210; 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