{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:13:43Z","timestamp":1792300423133,"version":"4.4.0"},"reference-count":37,"publisher":"National Academy of Sciences","issue":"47","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,11,20]]},"abstract":"<jats:p>\n                    Fungi in the genus\n                    <jats:italic>Malassezia<\/jats:italic>\n                    are ubiquitous skin residents of humans and other warm-blooded animals.\n                    <jats:italic>Malassezia<\/jats:italic>\n                    are involved in disorders including dandruff and seborrheic dermatitis, which together affect &gt;50% of humans. Despite the importance of\n                    <jats:italic>Malassezia<\/jats:italic>\n                    in common skin diseases, remarkably little is known at the molecular level. We describe the genome, secretory proteome, and expression of selected genes of\n                    <jats:italic>Malassezia globosa<\/jats:italic>\n                    . Further, we report a comparative survey of the genome and secretory proteome of\n                    <jats:italic>Malassezia restricta<\/jats:italic>\n                    , a close relative implicated in similar skin disorders. Adaptation to the skin environment and associated pathogenicity may be due to unique metabolic limitations and capabilities. For example, the lipid dependence of\n                    <jats:italic>M. globosa<\/jats:italic>\n                    can be explained by the apparent absence of a fatty acid synthase gene. The inability to synthesize fatty acids may be complemented by the presence of multiple secreted lipases to aid in harvesting host lipids. In addition, an abundance of genes encoding secreted hydrolases (e.g., lipases, phospholipases, aspartyl proteases, and acid sphingomyelinases) was found in the\n                    <jats:italic>M. globosa<\/jats:italic>\n                    genome. In contrast, the phylogenetically closely related plant pathogen\n                    <jats:italic>Ustilago maydis<\/jats:italic>\n                    encodes a different arsenal of extracellular hydrolases with more copies of glycosyl hydrolase genes.\n                    <jats:italic>M. globosa<\/jats:italic>\n                    shares a similar arsenal of extracellular hydrolases with the phylogenetically distant human pathogen,\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    , which occupies a similar niche, indicating the importance of host-specific adaptation. The\n                    <jats:italic>M. globosa<\/jats:italic>\n                    genome sequence also revealed the presence of mating-type genes, providing an indication that\n                    <jats:italic>Malassezia<\/jats:italic>\n                    may be capable of sex.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0706756104","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T21:05:21Z","timestamp":1194987921000},"page":"18730-18735","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":397,"title":["Dandruff-associated\n                    <i>Malassezia<\/i>\n                    genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens"],"prefix":"10.1073","volume":"104","author":[{"given":"Jun","family":"Xu","sequence":"first","affiliation":[{"name":"*Procter &amp; Gamble Co., Miami Valley Innovation Center, Cincinnati, OH 45253-8707;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles W.","family":"Saunders","sequence":"additional","affiliation":[{"name":"*Procter &amp; Gamble Co., Miami Valley Innovation Center, Cincinnati, OH 45253-8707;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Hu","sequence":"additional","affiliation":[{"name":"*Procter &amp; Gamble Co., Miami Valley Innovation Center, Cincinnati, OH 45253-8707;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond A.","family":"Grant","sequence":"additional","affiliation":[{"name":"*Procter &amp; Gamble Co., Miami Valley Innovation Center, Cincinnati, OH 45253-8707;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teun","family":"Boekhout","sequence":"additional","affiliation":[{"name":"Centraalbureau voor Schimmelcultures, Fungal Biodiversity Centre, 3584 CT, Utrecht, The Netherlands;"},{"name":"Division of Acute Medicine and Infectious Diseases and Eijkman\u2013Winkler Centre for Microbiology, Infectious Diseases and Inflammation, University Medical Centre, 3508 GA, Utrecht, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiko E.","family":"Kuramae","sequence":"additional","affiliation":[{"name":"Centraalbureau voor Schimmelcultures, Fungal Biodiversity Centre, 3584 CT, Utrecht, The Netherlands;"},{"name":"Netherlands Institute of Ecology, Centre for Terrestrial Ecology, 6666 ZG, Heteren, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Kronstad","sequence":"additional","affiliation":[{"name":"The Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC, Canada V6T 1Z4;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne M.","family":"DeAngelis","sequence":"additional","affiliation":[{"name":"*Procter &amp; Gamble Co., Miami Valley Innovation Center, Cincinnati, OH 45253-8707;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Reeder","sequence":"additional","affiliation":[{"name":"*Procter &amp; Gamble Co., Miami Valley Innovation Center, Cincinnati, OH 45253-8707;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R.","family":"Johnstone","sequence":"additional","affiliation":[{"name":"*Procter &amp; Gamble Co., Miami Valley Innovation Center, Cincinnati, OH 45253-8707;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Leland","sequence":"additional","affiliation":[{"name":"*Procter &amp; Gamble Co., Miami Valley Innovation Center, Cincinnati, OH 45253-8707;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Fieno","sequence":"additional","affiliation":[{"name":"*Procter &amp; Gamble Co., Miami Valley Innovation Center, Cincinnati, OH 45253-8707;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Begley","sequence":"additional","affiliation":[{"name":"*Procter &amp; Gamble Co., Miami Valley Innovation Center, Cincinnati, OH 45253-8707;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Sun","sequence":"additional","affiliation":[{"name":"*Procter &amp; Gamble Co., Miami Valley Innovation Center, Cincinnati, OH 45253-8707;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin P.","family":"Lacey","sequence":"additional","affiliation":[{"name":"*Procter &amp; Gamble Co., Miami Valley Innovation Center, Cincinnati, OH 45253-8707;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanuja","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"*Procter &amp; Gamble Co., Miami Valley Innovation Center, Cincinnati, OH 45253-8707;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Keough","sequence":"additional","affiliation":[{"name":"*Procter &amp; Gamble Co., Miami Valley Innovation Center, Cincinnati, OH 45253-8707;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lien","family":"Chu","sequence":"additional","affiliation":[{"name":"Integrated Genomics, 2201 West Campbell Park Drive, Suite 15, Chicago, IL 60612-3547; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Sears","sequence":"additional","affiliation":[{"name":"**Department of Biomedical Informatics and Pharmacology, Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yuan","sequence":"additional","affiliation":[{"name":"**Department of Biomedical Informatics and Pharmacology, Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Thomas L.","family":"Dawson","sequence":"additional","affiliation":[{"name":"*Procter &amp; Gamble Co., Miami Valley Innovation Center, Cincinnati, OH 45253-8707;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2007,11,20]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2005.00424.x"},{"key":"e_1_3_3_2_2","first-page":"259","volume-title":"Textbook of Cosmetic Dermatology","author":"Schwartz JR","year":"2004","unstructured":"JR Schwartz, CW Cardin, TL Dawson Textbook of Cosmetic Dermatology, eds R Baran, HI Maibach (Martin Dunitz, Ltd, London), pp. 259\u2013272 (2004)."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.1.21-57.2002"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.034"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.38.s1.9.16"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsyr.2005.05.006"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803123381102"},{"key":"e_1_3_3_8_2","first-page":"202","volume-title":"Topley and Wilson's Microbiology and Microbial Infections, Medical Mycology","author":"Crespo Erchiga V","year":"2005","unstructured":"V Crespo Erchiga, E Gu\u00e9ho Topley and Wilson's Microbiology and Microbial Infections, Medical Mycology, eds WG Merz, RJ Hay (Hodder Arnold, London), pp. 202\u2013243 (2005)."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2006.05.005"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000090246"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.9.3350-3357.2002"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/02681219880000581"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1095781"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki009"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05248"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.201167098"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700844"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/15572536.2006.11832620"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.31.1.245"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2006.04.002"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.1.5.704-718.2002"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.10.002"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.07.064"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5431.1271"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.9.4970-4976.2003"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0010001"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(01)02094-7"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.67.3.400-428.2003"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.10.4868-4869.2004"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780310001615367"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/17.suppl_1.S140"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.1998.5.681"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1865504"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/14.9.755"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.1.41"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-6-31"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.05.028"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.0706756104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T16:41:03Z","timestamp":1649781663000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.0706756104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,20]]},"references-count":37,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2007,11,20]]}},"alternative-id":["10.1073\/pnas.0706756104"],"URL":"https:\/\/doi.org\/10.1073\/pnas.0706756104","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1095957.559228","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1095957.551917","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,20]]},"assertion":[{"value":"2007-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}