{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:21:40Z","timestamp":1793175700519,"version":"4.5.0"},"reference-count":52,"publisher":"National Academy of Sciences","issue":"7","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2008,2,19]]},"abstract":"<jats:p>\n                    Transferrin receptor 1 (TfR1) is a cellular receptor for the New World hemorrhagic fever arenaviruses Machupo (MACV), Jun\u00edn (JUNV), and Guanarito (GTOV). Each of these viruses is specifically adapted to a distinct rodent host species, but all cause human disease. Here we compare the ability of these viruses to use various mammalian transferrin receptor 1 (TfR1) orthologs, including those of the South American rodents that serve as reservoirs for MACV, JUNV, and GTOV (\n                    <jats:italic>Calomys callosus<\/jats:italic>\n                    ,\n                    <jats:italic>Calomys musculinus<\/jats:italic>\n                    , and\n                    <jats:italic>Zygodontomys brevicauda<\/jats:italic>\n                    , respectively). Retroviruses pseudotyped with MACV and JUNV but not GTOV glycoproteins (GPs) efficiently used\n                    <jats:italic>C. callosus<\/jats:italic>\n                    TfR1, whereas only JUNV GP could use\n                    <jats:italic>C. musculinus<\/jats:italic>\n                    TfR1. All three viruses efficiently used\n                    <jats:italic>Z. brevicauda<\/jats:italic>\n                    TfR1. TfR1 orthologs from related rodents, including house mouse (\n                    <jats:italic>Mus musculus<\/jats:italic>\n                    ) and rat (\n                    <jats:italic>Rattus norvegicus<\/jats:italic>\n                    ), did not support entry of these viruses. In contrast, these viruses efficiently used human and domestic cat TfR1 orthologs. We further show that a local region of the human TfR1 apical domain, including tyrosine 211, determined the efficiency with which MACV, JUNV, and GTOV used various TfR1 orthologs. Our data show that these New World arenaviruses are specifically adapted to the TfR1 orthologs of their respective rodent hosts and identify key commonalities between these orthologs and human TfR1 necessary for efficient transmission of these viruses to humans.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0709254105","type":"journal-article","created":{"date-parts":[[2008,2,11]],"date-time":"2008-02-11T21:40:28Z","timestamp":1202766028000},"page":"2664-2669","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":134,"title":["Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses"],"prefix":"10.1073","volume":"105","author":[{"given":"Sheli R.","family":"Radoshitzky","sequence":"first","affiliation":[{"name":"*Department of Microbiology and Molecular Genetics and New England Primate Research Center, Harvard Medical School, Southborough, MA 01772;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens H.","family":"Kuhn","sequence":"additional","affiliation":[{"name":"*Department of Microbiology and Molecular Genetics and New England Primate Research Center, Harvard Medical School, Southborough, MA 01772;"},{"name":"Department of Biology, Chemistry, and Pharmacy, Freie Universit\u00e4t Berlin, 14195 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina F.","family":"Spiropoulou","sequence":"additional","affiliation":[{"name":"Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar G.","family":"Albari\u00f1o","sequence":"additional","affiliation":[{"name":"Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan P.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Salazar-Bravo","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Center for Epidemiology and Zoonoses, Texas Tech University, Lubbock, TX 79409; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Dorfman","sequence":"additional","affiliation":[{"name":"*Department of Microbiology and Molecular Genetics and New England Primate Research Center, Harvard Medical School, Southborough, MA 01772;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S.","family":"Lee","sequence":"additional","affiliation":[{"name":"*Department of Microbiology and Molecular Genetics and New England Primate Research Center, Harvard Medical School, Southborough, MA 01772;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enxiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Abramson Family Cancer Center, University of Pennsylvania, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Abramson Family Cancer Center, University of Pennsylvania, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeryun","family":"Choe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Farzan","sequence":"additional","affiliation":[{"name":"*Department of Microbiology and Molecular Genetics and New England Primate Research Center, Harvard Medical School, Southborough, MA 01772;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2008,2,19]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"V","article-title":"Arenaviruses I: The epidemiology molecular and cell biology of arenaviruses.","volume":"262","author":"Oldstone MB","year":"2002","unstructured":"MB Oldstone, Arenaviruses I: The epidemiology molecular and cell biology of arenaviruses. Curr Top Microbiol Immunol 262, V\u2013XII (2002).","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(02)00202-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.02.008"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.18.2391"},{"key":"e_1_3_3_5_2","first-page":"25","article-title":"Mammalian reservoirs of arenaviruses.","volume":"262","author":"Salazar-Bravo J","year":"2002","unstructured":"J Salazar-Bravo, LA Ruedas, TL Yates, Mammalian reservoirs of arenaviruses. Curr Top Microbiol Immunol 262, 25\u201363 (2002).","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_3_6_2","first-page":"1","article-title":"Molecular phylogeny of the arenaviruses.","volume":"262","author":"Clegg JC","year":"2002","unstructured":"JC Clegg, Molecular phylogeny of the arenaviruses. Curr Top Microbiol Immunol 262, 1\u201324 (2002).","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3703.1618"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1966.15.103"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.61.325"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1991.44.589"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-1348(01)00003-X"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/mpev.1997.0436"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.61.4.982-985.1987"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6822(03)00421-5"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.221447598"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.5.2866-2872.2003"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(95)00057-1"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1326"},{"key":"e_1_3_3_19_2","first-page":"111","article-title":"Receptor structure, binding, and cell entry of arenaviruses.","volume":"262","author":"Kunz S","year":"2002","unstructured":"S Kunz, P Borrow, MB Oldstone, Receptor structure, binding, and cell entry of arenaviruses. Curr Top Microbiol Immunol 262, 111\u2013137 (2002).","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/09687860400017784"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-1-1"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.08.030"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01321064"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00008-06"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5396.2079"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.10.5979-5987.2005"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.10.5140-5146.2002"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05539"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82808-0"},{"key":"e_1_3_3_30_2","first-page":"V","article-title":"Arenaviruses II: The molecular pathogenesis of arenavirus infections.","volume":"263","author":"Oldstone MB","year":"2002","unstructured":"MB Oldstone, Arenaviruses II: The molecular pathogenesis of arenavirus infections. Curr Top Microbiol Immunol 263, V\u2013XII (2002).","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.06.010"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.36.5.539"},{"key":"e_1_3_3_33_2","first-page":"477","article-title":"Pathology of Bolivian hemorrhagic fever in the rhesus monkey.","volume":"73","author":"Terrell TG","year":"1973","unstructured":"TG Terrell, JL Stookey, GA Eddy, MD Kastello, Pathology of Bolivian hemorrhagic fever in the rhesus monkey. Am J Pathol 73, 477\u2013494 (1973).","journal-title":"Am J Pathol"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/312162a0"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200205001-00016"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(84)90178-3"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.20.3.776-781.1978"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01397-07"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.03.003"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.05.018"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.02.033"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511572200"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5440.779"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/47417"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00130-8"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/133.1.57"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/152.1.218"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1967.16.531"},{"key":"e_1_3_3_49_2","first-page":"493","article-title":"Infection of wild and laboratory animals with Machupo and Latino viruses.","volume":"52","author":"Webb PA","year":"1975","unstructured":"PA Webb, G Justines, KM Johnson, Infection of wild and laboratory animals with Machupo and Latino viruses. Bull WHO 52, 493\u2013499 (1975).","journal-title":"Bull WHO"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1994.50.452"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(96)00674-9"},{"key":"e_1_3_3_52_2","first-page":"23","article-title":"Aerosol infection of rhesus macaques with Junin virus.","volume":"33","author":"Kenyon RH","year":"1992","unstructured":"RH Kenyon, et al., Aerosol infection of rhesus macaques with Junin virus. Intervirology 33, 23\u201331 (1992).","journal-title":"Intervirology"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.0709254105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T16:20:53Z","timestamp":1649780453000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.0709254105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,19]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,2,19]]}},"alternative-id":["10.1073\/pnas.0709254105"],"URL":"https:\/\/doi.org\/10.1073\/pnas.0709254105","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,19]]},"assertion":[{"value":"2007-09-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-02-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}