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Data from a genome-wide transcriptomic study were used to compare the expression of 80 metabolically relevant nuclear genes from laser-capture microdissected non-tangle-bearing neurons from autopsy brains of AD cases and normal controls in posterior cingulate cortex, which is metabolically affected in the earliest stages; other brain regions metabolically affected in PET studies of AD or normal aging; and visual cortex, which is relatively spared. Compared with controls, AD cases had significantly lower expression of 70% of the nuclear genes encoding subunits of the mitochondrial electron transport chain in posterior cingulate cortex, 65% of those in the middle temporal gyrus, 61% of those in hippocampal CA1, 23% of those in entorhinal cortex, 16% of those in visual cortex, and 5% of those in the superior frontal gyrus. Western blots confirmed underexpression of those complex I\u2013V subunits assessed at the protein level. Cerebral metabolic rate for glucose abnormalities in FDG PET studies of AD may be associated with reduced neuronal expression of nuclear genes encoding subunits of the mitochondrial electron transport chain.<\/jats:p>","DOI":"10.1073\/pnas.0709259105","type":"journal-article","created":{"date-parts":[[2008,3,10]],"date-time":"2008-03-10T23:34:04Z","timestamp":1205192044000},"page":"4441-4446","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":529,"title":["Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons"],"prefix":"10.1073","volume":"105","author":[{"given":"Winnie S.","family":"Liang","sequence":"first","affiliation":[{"name":"*Neurogenomics Division, Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, AZ 85004;"},{"name":"Arizona Alzheimer's Consortium, 901 East Willetta Street, Phoenix, AZ 85006;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Reiman","sequence":"additional","affiliation":[{"name":"*Neurogenomics Division, Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, AZ 85004;"},{"name":"Arizona Alzheimer's Consortium, 901 East Willetta Street, Phoenix, AZ 85006;"},{"name":"Banner Alzheimer's Institute, 901 East Willetta Street Phoenix, AZ 85006;"},{"name":"Department of Psychiatry and Evelyn F. 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