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Our experiments in frog and rat venular microvessels under a variety of conditions revealed the same time trend for new steady states to be established as in Michel and Phillips' experiments. In contrast, one theoretically predicts herein that the time required for the tissue albumin concentration to increase to values for a new steady state to be achieved through reabsorption is in the order of several hours. In this paper we propose a new hypothesis and theoretical model for this rapid regulation, namely that pericytes covering the interendothelial cleft exits create small trapped microdomains outside the cleft exits which regulate this transient behavior. Our electron microscopy studies on rat mesenteric venular microvessels reveal an average pericyte coverage of \u224885%. The theoretical model based on this ultrastructural study predicts an equilibration time on the order of 1 min when the lumen pressure is abruptly lowered. The basic concept of a trapped microdomain can also be extended to microdomains in the interstitial space surrounding skeletal muscle capillaries.<\/jats:p>","DOI":"10.1073\/pnas.0710986105","type":"journal-article","created":{"date-parts":[[2008,1,23]],"date-time":"2008-01-23T21:00:17Z","timestamp":1201122017000},"page":"1374-1379","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":25,"title":["Transient regulation of transport by pericytes in venular microvessels via trapped microdomains"],"prefix":"10.1073","volume":"105","author":[{"given":"X.","family":"Zhang","sequence":"first","affiliation":[{"name":"*The Leni and Peter W. May Department of Orthopaedics, Mount Sinai School of Medicine, New York, NY 10029;"},{"name":"Department of Biomedical Engineering, The City College of The City University of New York, New York, NY 10031; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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