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In addition to the life-threatening hemorrhagic anemia, platelet-depleted mice fail to mount an efficient cytotoxic T lymphocyte (CTL) response and cannot clear LCMV. Transfusion of functional platelets into these animals reduces hemorrhage, prevents death and restores CTL-induced viral clearance in a manner partially dependent on CD40 ligand (CD40L). These results indicate that, upon activation, platelets expressing integrin \u03b23 and CD40L are required for protecting the host against the induction of an IFN-\u03b1\/\u03b2-dependent lethal hemorrhagic diathesis and for clearing LCMV infection through CTLs.<\/jats:p>","DOI":"10.1073\/pnas.0711200105","type":"journal-article","created":{"date-parts":[[2008,1,9]],"date-time":"2008-01-09T21:05:49Z","timestamp":1199912749000},"page":"629-634","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":120,"title":["Platelets prevent IFN-\u03b1\/\u03b2-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus"],"prefix":"10.1073","volume":"105","author":[{"given":"Matteo","family":"Iannacone","sequence":"first","affiliation":[{"name":"Departments of *Molecular and Experimental Medicine and"},{"name":"Immunopathogenesis of Liver Infections Unit, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Sitia","sequence":"additional","affiliation":[{"name":"Immunopathogenesis of Liver Infections Unit, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Isogawa","sequence":"additional","affiliation":[{"name":"Departments of *Molecular and Experimental Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason K.","family":"Whitmire","sequence":"additional","affiliation":[{"name":"Molecular and Integrative Neurosciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Marchese","sequence":"additional","affiliation":[{"name":"Departments of *Molecular and Experimental Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis V.","family":"Chisari","sequence":"additional","affiliation":[{"name":"Departments of *Molecular and Experimental Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaverio M.","family":"Ruggeri","sequence":"additional","affiliation":[{"name":"Departments of *Molecular and Experimental Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca G.","family":"Guidotti","sequence":"additional","affiliation":[{"name":"Departments of *Molecular and Experimental Medicine and"},{"name":"Immunopathogenesis of Liver Infections Unit, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2008,1,15]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"83","article-title":"Biology and pathogenesis of lymphocytic choriomeningitis virus infection.","volume":"263","author":"Oldstone MB","year":"2002","unstructured":"MB Oldstone, Biology and pathogenesis of lymphocytic choriomeningitis virus infection. 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