{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:44:38Z","timestamp":1791330278937,"version":"4.3.1"},"reference-count":31,"publisher":"National Academy of Sciences","issue":"29","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2008,7,22]]},"abstract":"<jats:p>\n                    Changes in life history are expected when new sources of extrinsic mortality impact on natural populations. We report a new disease, devil facial tumor disease, causing an abrupt transition from iteroparity toward single breeding in the largest extant carnivorous marsupial, the Tasmanian devil (\n                    <jats:italic>Sarcophilus harrisii<\/jats:italic>\n                    ), in which males can weigh as much as 14 kg and females 9 kg. This change in life history is associated with almost complete mortality of individuals from this infectious cancer past their first year of adult life. Devils have shown their capacity to respond to this disease-induced increased adult mortality with a 16-fold increase in the proportion of individuals exhibiting precocious sexual maturity. These patterns are documented in five populations where there are data from before and after disease arrival and subsequent population impacts. To our knowledge, this is the first known case of infectious disease leading to increased early reproduction in a mammal. The persistence of both this disease and the associated life-history changes pose questions about longer-term evolutionary responses and conservation prospects for this iconic species.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0711236105","type":"journal-article","created":{"date-parts":[[2008,7,14]],"date-time":"2008-07-14T21:09:56Z","timestamp":1216069796000},"page":"10023-10027","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":231,"title":["Life-history change in disease-ravaged Tasmanian devil populations"],"prefix":"10.1073","volume":"105","author":[{"given":"Menna E.","family":"Jones","sequence":"first","affiliation":[{"name":"*School of Zoology, University of Tasmania, Hobart TAS 7001, Australia;"},{"name":"School of Botany and Zoology, Australian National University, Canberra ACT 0200, Australia;"},{"name":"Wildlife Management Branch and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Cockburn","sequence":"additional","affiliation":[{"name":"School of Botany and Zoology, Australian National University, Canberra ACT 0200, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Hamede","sequence":"additional","affiliation":[{"name":"*School of Zoology, University of Tasmania, Hobart TAS 7001, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Hawkins","sequence":"additional","affiliation":[{"name":"*School of Zoology, University of Tasmania, Hobart TAS 7001, Australia;"},{"name":"Biodiversity Conservation Branch, Department of Primary Industry and Water, Hobart TAS 7001, Australia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Hesterman","sequence":"additional","affiliation":[{"name":"*School of Zoology, University of Tasmania, Hobart TAS 7001, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly","family":"Lachish","sequence":"additional","affiliation":[{"name":"School of Integrative Biology, University of Queensland, St. Lucia QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Mann","sequence":"additional","affiliation":[{"name":"Wildlife Management Branch and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamish","family":"McCallum","sequence":"additional","affiliation":[{"name":"*School of Zoology, University of Tasmania, Hobart TAS 7001, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pemberton","sequence":"additional","affiliation":[{"name":"Biodiversity Conservation Branch, Department of Primary Industry and Water, Hobart TAS 7001, Australia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2008,7,22]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/346357a0"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02430"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1890\/0012-9658(2002)083[2841:APFPAO]2.0.CO;2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1890\/03-0009"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1139\/f05-079"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1420-9101.1992.5030491.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(00)00389-0"},{"key":"e_1_3_3_8_2","first-page":"291","article-title":"Parasitic effects on host life-history traits: A review of recent studies","volume":"1","author":"Michalakis Y","year":"1994","unstructured":"Y Michalakis, ME Hochberg, Parasitic effects on host life-history traits: A review of recent studies. Parasite J Soc Fr Parasitol 1, 291\u2013294 (1994).","journal-title":"Parasite J Soc Fr Parasitol"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocon.2006.04.010"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10393-007-0118-0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/439549a"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10393-007-0126-0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704580104"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9993.2007.01827.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1461-0248.2004.00693.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2656.2007.01272.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.26749\/rstpp.112.161"},{"key":"e_1_3_3_18_2","unstructured":"D Pemberton Social organisation and behaviour of the Tasmanian devil Sarcophilus harrisii.  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Proc Natl Acad Sci USA 21, 394\u2013407 (2007).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.2307\/5744"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2004.02239.x"},{"key":"e_1_3_3_31_2","unstructured":"H Hesterman Reproductive physiology of the Tasmanian devil (Sarcophilus harrisii) and spotted-tailed quoll (Dasyurus maculatus).  (Univ of Tasmania Hobart PhD thesis. 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