{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:00:38Z","timestamp":1791201638931,"version":"4.2.0"},"reference-count":28,"publisher":"National Academy of Sciences","issue":"6","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2008,2,12]]},"abstract":"<jats:p>\n                    Although leptin is known for its regulation of food intake, it has many emerging roles in immune function. To better define the role of leptin in hematopoietic processes, a leptin-deficient obese mouse (\n                    <jats:italic>ob<\/jats:italic>\n                    \/\n                    <jats:italic>ob<\/jats:italic>\n                    ) and C57BL\/6 lean wild-type controls were compared. Despite their large size and consumption of substantial amounts of nutrients, the\n                    <jats:italic>ob<\/jats:italic>\n                    \/\n                    <jats:italic>ob<\/jats:italic>\n                    mice had only 60% as many nucleated cells in their marrow as controls. The greatest impact of leptin deficiency was on the B cell compartment that had 70% fewer cells, reducing the absolute number of pre-B and immature B cells to 21% and 12% of normal, respectively, and indicating a significant reduction in lymphopoiesis in\n                    <jats:italic>ob<\/jats:italic>\n                    \/\n                    <jats:italic>ob<\/jats:italic>\n                    mice. Whereas the proportion of myeloids remained nearly normal in the obese mice, they also exhibited a reduction of 40% and 25%, respectively, in absolute numbers of granulocytes and monocytes. Seven days of provision of recombinant leptin promoted substantial lymphopoiesis, increasing the numbers of B cells in the marrow of the obese mice twofold, while doubling and tripling, respectively, the numbers of pre-B and immature B cells. Twelve days of supplementation brought these subpopulations to near-normal proportions. Leptin treatment also facilitated myelopoiesis such that the marrow of the obese mice contained normal numbers of monocytes and granulocytes after 7 days. Taken together, the data support an important role for leptin in sustaining lymphopoiesis and myelopoiesis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0712053105","type":"journal-article","created":{"date-parts":[[2008,2,4]],"date-time":"2008-02-04T20:59:53Z","timestamp":1202158793000},"page":"2017-2021","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":154,"title":["A role for leptin in sustaining lymphopoiesis and myelopoiesis"],"prefix":"10.1073","volume":"105","author":[{"given":"Kate","family":"Claycombe","sequence":"first","affiliation":[{"name":"Departments of *Food Science and Human Nutrition and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis E.","family":"King","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824-1319"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"Fraker","sequence":"additional","affiliation":[{"name":"Departments of *Food Science and Human Nutrition and"},{"name":"Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824-1319"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2008,2,12]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7624777"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7624778"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/379632a0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81294-5"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.1.182"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200506-909OC"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1350"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.2.875"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.8.4018"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.11.6820"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16721"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)70684-2"},{"key":"e_1_3_3_13_2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1189\/jlb.68.4.437","article-title":"Leptin in the regulation of immunity, inflammation, and hematopoiesis.","volume":"68","author":"Fantuzzi G","year":"2000","unstructured":"G Fantuzzi, R Faggioni, Leptin in the regulation of immunity, inflammation, and hematopoiesis. 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