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Comparative genomic analysis localizes human\n                    <jats:italic>RAB38<\/jats:italic>\n                    to the mouse chocolate (\n                    <jats:italic>cht<\/jats:italic>\n                    ) locus. A G146T mutation occurs in the conserved GTP binding domain of RAB38 in\n                    <jats:italic>cht<\/jats:italic>\n                    mice.\n                    <jats:italic>Rab38<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>cht<\/jats:italic>\n                    <\/jats:sup>\n                    <jats:italic>\/Rab38<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>cht<\/jats:italic>\n                    <\/jats:sup>\n                    mice exhibit a brown coat similar in color to mice with a mutation in tyrosinase-related protein 1 (\n                    <jats:italic>Tyrp1<\/jats:italic>\n                    ), a mouse model for oculocutaneous albinism. The targeting of TYRP1 protein to the melanosome is impaired in\n                    <jats:italic>Rab38<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>cht<\/jats:italic>\n                    <\/jats:sup>\n                    <jats:italic>\/Rab38<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>cht<\/jats:italic>\n                    <\/jats:sup>\n                    melanocytes. These observations, and the fact that green fluorescent protein-tagged RAB38 colocalizes with end-stage melanosomes in wild-type melanocytes, suggest that RAB38 plays a role in the sorting of TYRP1. This study demonstrates the utility of expression profile analysis to identify mammalian disease genes.\n                  <\/jats:p>","DOI":"10.1073\/pnas.072087599","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:37:36Z","timestamp":1027679856000},"page":"4471-4476","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":154,"title":["Mutation of melanosome protein RAB38 in\n                    <i>chocolate<\/i>\n                    mice"],"prefix":"10.1073","volume":"99","author":[{"given":"Stacie K.","family":"Loftus","sequence":"first","affiliation":[{"name":"Genetic Disease Research Branch and Cancer Genetics Branch, National Human Genome Research Institute, Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; and Graduate Genetics Program, George Washington University, Washington, DC 20052"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise M.","family":"Larson","sequence":"additional","affiliation":[{"name":"Genetic Disease Research Branch and Cancer Genetics Branch, National Human Genome Research Institute, Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; 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