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Here we show that mice lacking\n                    <jats:italic>Slit3<\/jats:italic>\n                    developed a central (septum transversum) CDH.\n                    <jats:italic>Slit3<\/jats:italic>\n                    encodes a member of the Slit family of guidance molecules and is expressed predominantly in the mesothelium of the diaphragm during embryonic development. In\n                    <jats:italic>Slit3<\/jats:italic>\n                    null mice, the central tendon region of the diaphragm fails to separate from liver tissue because of abnormalities in morphogenesis. The CDH progresses through continuous growth of the liver into the thoracic cavity. This study establishes the first genetic model for CDH and identifies a previously unsuspected role for Slit3 in regulating the development of the diaphragm.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0730709100","type":"journal-article","created":{"date-parts":[[2003,4,29]],"date-time":"2003-04-29T12:23:56Z","timestamp":1051619036000},"page":"5217-5222","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":123,"title":["A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking\n                    <i>Slit3<\/i>"],"prefix":"10.1073","volume":"100","author":[{"given":"Wenlin","family":"Yuan","sequence":"first","affiliation":[{"name":"Departments of Molecular Biology and Pharmacology, Anatomy and Neurobiology, and Pediatrics, Washington University School of Medicine, St. Louis, MO 63110; and Department of Physiology, University of Alberta, Edmonton, AB, Canada T6G 2S2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Rao","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Pharmacology, Anatomy and Neurobiology, and Pediatrics, Washington University School of Medicine, St. Louis, MO 63110; and Department of Physiology, University of Alberta, Edmonton, AB, Canada T6G 2S2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randal P.","family":"Babiuk","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Pharmacology, Anatomy and Neurobiology, and Pediatrics, Washington University School of Medicine, St. Louis, MO 63110; and Department of Physiology, University of Alberta, Edmonton, AB, Canada T6G 2S2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Greer","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Pharmacology, Anatomy and Neurobiology, and Pediatrics, Washington University School of Medicine, St. Louis, MO 63110; and Department of Physiology, University of Alberta, Edmonton, AB, Canada T6G 2S2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Pharmacology, Anatomy and Neurobiology, and Pediatrics, Washington University School of Medicine, St. Louis, MO 63110; and Department of Physiology, University of Alberta, Edmonton, AB, Canada T6G 2S2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Ornitz","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Pharmacology, Anatomy and Neurobiology, and Pediatrics, Washington University School of Medicine, St. Louis, MO 63110; and Department of Physiology, University of Alberta, Edmonton, AB, Canada T6G 2S2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2003,4,17]]},"reference":[{"key":"e_1_3_3_1_2","volume-title":"Nyhus and Condon's Hernia","author":"Laberg J-M","year":"1995","unstructured":"J-M Laberg, D L Sigalet, F M Guttman Nyhus and Condon's Hernia, eds R J Fitzgibbons, A G Greenburg (Lippincott, Philadelphia, 1995)."},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420460605"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510290064038"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30214-8"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-87767-4_8"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(200005)29:5<394::AID-PPUL9>3.0.CO;2-2"},{"key":"e_1_3_3_7_2","first-page":"L1159","volume":"279","author":"Guilbert T W","year":"2000","unstructured":"T W Guilbert, S A Gebb, J M Shannon Am J Physiol 279, L1159\u2013L1171 (2000).","journal-title":"Am J Physiol"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65000-6"},{"key":"e_1_3_3_9_2","volume-title":"Human Embryology","author":"Larsen W J","year":"2001","unstructured":"W J Larsen Human Embryology (Churchill Livingstone, 3rd Ed., New York, 2001).","edition":"3"},{"key":"e_1_3_3_10_2","volume-title":"The Anatomical Basis of Mouse Development","author":"Kaufman M H","year":"1999","unstructured":"M H Kaufman, J B L Bard The Anatomical Basis of Mouse Development (Academic, San Diego, 1999)."},{"key":"e_1_3_3_11_2","unstructured":"Babiuk R. 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