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Male mice that are homozygous for a targeted mutation in the\n                    <jats:italic>Pkdrej<\/jats:italic>\n                    allele (\n                    <jats:italic>\n                      Pkdrej\n                      <jats:sup>tm\/tm<\/jats:sup>\n                    <\/jats:italic>\n                    ) are fertile in unrestricted mating trials, but exhibit lower reproductive success when competing with wild-type males in sequential mating trials and in artificial insemination of mixed-sperm populations. Following mating, sperm from\n                    <jats:italic>\n                      Pkdrej\n                      <jats:sup>tm\/tm<\/jats:sup>\n                    <\/jats:italic>\n                    mice require &gt;2 h longer than those of wild-type males to be detected within the egg\/cumulus complex in the oviduct. Sperm from mice of both genotypes are able to capacitate\n                    <jats:italic>in vitro<\/jats:italic>\n                    . However, one of the component processes of capacitation, the ability to undergo a zona pellucida\u2013evoked acrosome reaction, develops more slowly in sperm from\n                    <jats:italic>\n                      Pkdrej\n                      <jats:sup>tm\/tm<\/jats:sup>\n                    <\/jats:italic>\n                    animals than in sperm from wild-type males. In contrast, a second component process of capacitation, the transition to hyperactivated flagellar motility, develops with a similar time course in both genotypes. These two behavioral consequences of capacitation, exocytotic competence and altered motility, are therefore differentially regulated. These data suggest that\n                    <jats:italic>Pkdrej<\/jats:italic>\n                    controls the timing of fertilization\n                    <jats:italic>in vivo<\/jats:italic>\n                    through effects on sperm transport and exocytotic competence and is a factor in postcopulatory sexual selection.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0800603105","type":"journal-article","created":{"date-parts":[[2008,6,18]],"date-time":"2008-06-18T21:35:49Z","timestamp":1213824949000},"page":"8661-8666","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":70,"title":["A polycystin-1 controls postcopulatory reproductive selection in mice"],"prefix":"10.1073","volume":"105","author":[{"given":"Keith A.","family":"Sutton","sequence":"first","affiliation":[{"name":"*Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa K.","family":"Jungnickel","sequence":"additional","affiliation":[{"name":"*Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey M.","family":"Florman","sequence":"additional","affiliation":[{"name":"*Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2008,6,24]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90137-6"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01743.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0888-7543(03)00048-X"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-005-1431-5"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.07.007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1076"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2005.12.005"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602702103"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05084"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.3.543"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.20410"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/518695"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg733"},{"key":"e_1_3_3_14_2","first-page":"189","volume-title":"The Physiology of Reproduction","author":"Yanagimachi R","year":"1994","unstructured":"R Yanagimachi, Mammalian fertilization. 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