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Properdin binding was facilitated by the glycosaminoglycan chains of surface proteoglycans. Properdin released by activated neutrophils was particularly effective at recognition of apoptotic T cells, whereas the binding activity of properdin in the serum appeared to be inhibited. \u201cProperdin tagging\u201d of apoptotic T cells also induced their uptake by phagocytes independent of complement activation or other complement proteins. Although our findings were made primarily with apoptotic T cells, they suggest that properdin could play a similar role during apoptosis of other cell types.<\/jats:p>","DOI":"10.1073\/pnas.0801015105","type":"journal-article","created":{"date-parts":[[2008,6,25]],"date-time":"2008-06-25T21:40:35Z","timestamp":1214430035000},"page":"9023-9028","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":138,"title":["The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis"],"prefix":"10.1073","volume":"105","author":[{"given":"Claudia","family":"Kemper","sequence":"first","affiliation":[{"name":"*Department of Medicine, Division of Rheumatology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne M.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"*Department of Medicine, Division of Rheumatology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis E.","family":"Hourcade","sequence":"additional","affiliation":[{"name":"*Department of Medicine, Division of Rheumatology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2008,7]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1972.33"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/35037728"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/35037722"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0211638"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri957"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI14122"},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.4049\/jimmunol.148.7.2207","article-title":"Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages","volume":"148","author":"Fadok VA","year":"1992","unstructured":"VA Fadok, et al., Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. 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