{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:56:17Z","timestamp":1792079777364,"version":"4.4.0"},"reference-count":28,"publisher":"National Academy of Sciences","issue":"27","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2008,7,8]]},"abstract":"<jats:p>\n                    Emerging evidence suggests that myocyte enhancer factor 2 (MEF2) transcription factors act as effectors of neurogenesis in the brain, with MEF2C the predominant isoform in developing cerebrocortex. Here, we show that conditional knockout of\n                    <jats:italic>Mef2c<\/jats:italic>\n                    in nestin-expressing neural stem\/progenitor cells (NSCs) impaired neuronal differentiation\n                    <jats:italic>in vivo<\/jats:italic>\n                    , resulting in aberrant compaction and smaller somal size. NSC proliferation and survival were not affected. Conditional null mice surviving to adulthood manifested more immature electrophysiological network properties and severe behavioral deficits reminiscent of Rett syndrome, an autism-related disorder. Our data support a crucial role for MEF2C in programming early neuronal differentiation and proper distribution within the layers of the neocortex.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0802876105","type":"journal-article","created":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T20:55:03Z","timestamp":1214945703000},"page":"9397-9402","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":256,"title":["Transcription factor MEF2C influences neural stem\/progenitor cell differentiation and maturation\n                    <i>in vivo<\/i>"],"prefix":"10.1073","volume":"105","author":[{"given":"Hao","family":"Li","sequence":"first","affiliation":[{"name":"*Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan C.","family":"Radford","sequence":"additional","affiliation":[{"name":"*Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Ragusa","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Sciences, Albany Medical Center, Albany, NY 12208; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Shea","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Sciences, Albany Medical Center, Albany, NY 12208; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott R.","family":"McKercher","sequence":"additional","affiliation":[{"name":"*Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Zaremba","sequence":"additional","affiliation":[{"name":"*Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Soussou","sequence":"additional","affiliation":[{"name":"*Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Nie","sequence":"additional","affiliation":[{"name":"*Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon-Joo","family":"Kang","sequence":"additional","affiliation":[{"name":"*Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuki","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"*Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-ichi","family":"Okamoto","sequence":"additional","affiliation":[{"name":"*Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Sciences, Albany Medical Center, Albany, NY 12208; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart A.","family":"Lipton","sequence":"additional","affiliation":[{"name":"*Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA 92037;"},{"name":"Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2008,7,8]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1122511"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.4.1546"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.11.5282"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.120.5.1251"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-08-05727.1995"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.10.2045"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5317.1404"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.130502697"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1122513"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0134-08.2008"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/12703"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(96)00135-0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(02)00322-7"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80778-3"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/374719a0"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(03)00013-8"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00777-8"},{"key":"e_1_3_3_18_2","doi-asserted-by":"crossref","unstructured":"A Chenn et al. Development of the Cerebral Cortex: Mechanisms Controlling Cell Fate Laminar and Areal Patterning and Axonal Connectivity.  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