{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:58:02Z","timestamp":1791417482379,"version":"4.3.3"},"reference-count":24,"publisher":"National Academy of Sciences","issue":"25","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2008,6,24]]},"abstract":"<jats:p>\n                    Endocannabinoids (eCBs) have recently been identified as axon guidance cues shaping the connectivity of local GABAergic interneurons in the developing cerebrum. However, eCB functions during pyramidal cell specification and establishment of long-range axonal connections are unknown. Here, we show that eCB signaling is operational in subcortical proliferative zones from embryonic day 12 in the mouse telencephalon and controls the proliferation of pyramidal cell progenitors and radial migration of immature pyramidal cells. When layer patterning is accomplished, developing pyramidal cells rely on eCB signaling to initiate the elongation and fasciculation of their long-range axons. Accordingly, CB\n                    <jats:sub>1<\/jats:sub>\n                    cannabinoid receptor (CB\n                    <jats:sub>1<\/jats:sub>\n                    R) null and pyramidal cell-specific conditional mutant (CB\n                    <jats:sub>1<\/jats:sub>\n                    R\n                    <jats:sup>f\/f,NEX-Cre<\/jats:sup>\n                    ) mice develop deficits in neuronal progenitor proliferation and axon fasciculation. Likewise, axonal pathfinding becomes impaired after\n                    <jats:italic>in utero<\/jats:italic>\n                    pharmacological blockade of CB\n                    <jats:sub>1<\/jats:sub>\n                    Rs. Overall, eCBs are fundamental developmental cues controlling pyramidal cell development during corticogenesis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0803545105","type":"journal-article","created":{"date-parts":[[2008,6,18]],"date-time":"2008-06-18T21:35:49Z","timestamp":1213824949000},"page":"8760-8765","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":298,"title":["Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning"],"prefix":"10.1073","volume":"105","author":[{"given":"Jan","family":"Mulder","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Retzius v\u00e4g 8, and"},{"name":"School of Medical Sciences, University of Aberdeen, AB25 2ZD Aberdeen, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Aguado","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology I, School of Biology, and Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas, Complutense University, 28040 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Keimpema","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Aberdeen, AB25 2ZD Aberdeen, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaudia","family":"Barab\u00e1s","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Aberdeen, AB25 2ZD Aberdeen, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos J.","family":"Ballester Rosado","sequence":"additional","affiliation":[{"name":"Developmental Neurobiology Program and Department of Pediatrics, Baylor College of Medicine, Feigin Center, 1102 Bates Street, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Molecular Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"Monory","sequence":"additional","affiliation":[{"name":"Department of Physiological Chemistry, Johannes Gutenberg University, 55128 Mainz, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Marsicano","sequence":"additional","affiliation":[{"name":"Department of Physiological Chemistry, Johannes Gutenberg University, 55128 Mainz, Germany;"},{"name":"AVENIR INSERM, Institut National de la Sante et de la Recherche Medicale, Institute Francois Magendie, 146 rue L\u00e9o Saignat, 33076 Bordeaux, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Di Marzo","sequence":"additional","affiliation":[{"name":"Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin L.","family":"Hurd","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry, Pharmacology, and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Guillemot","sequence":"additional","affiliation":[{"name":"Division of Molecular Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Mackie","sequence":"additional","affiliation":[{"name":"Gill Center and Department of Psychological and Brain Sciences, Indiana University, 1101 East 10th Street, Bloomington, IN 47405"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Lutz","sequence":"additional","affiliation":[{"name":"Department of Physiological Chemistry, Johannes Gutenberg University, 55128 Mainz, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology I, School of Biology, and Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas, Complutense University, 28040 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Chen","family":"Lu","sequence":"additional","affiliation":[{"name":"Developmental Neurobiology Program and Department of Pediatrics, Baylor College of Medicine, Feigin Center, 1102 Bates Street, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael","family":"Galve-Roperh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology I, School of Biology, and Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas, Complutense University, 28040 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Harkany","sequence":"additional","affiliation":[{"name":"Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles v\u00e4g 1, Karolinska Institutet, 17177 Stockholm, Sweden;"},{"name":"School of Medical Sciences, University of Aberdeen, AB25 2ZD Aberdeen, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2008,6,24]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhk036"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.01.018"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.042"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0372-06.2006"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4872-05.2006"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3101-05.2006"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509494102"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1137406"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200305129"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2008.02.001"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.07.006"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00020-4"},{"key":"e_1_3_3_13_2","first-page":"83","article-title":"Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat","volume":"14","author":"Bayer SA","year":"1993","unstructured":"SA Bayer, J Altman, RJ Russo, X Zhang, Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. 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