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Because the degradation of HIF-1\u03b1 is regulated by prolyl hydroxylases, we examined the effect of systemic administration of a prolyl hydroxylase inhibitor, dimethyloxalylglycine, in the OIR model. Our results determine that stabilizing HIF activity in the early phase of OIR prevents the oxygen-induced central vessel loss and subsequent vascular tortuosity and tufting that is characteristic of OIR. Overall, these findings imply that simulating hypoxia chemically by stabilizing HIF activity during the causative ischemia phase (hyperoxia) of retinopathy of prematurity may be of therapeutic value in preventing progression to the proliferative stage of the disease.<\/jats:p>","DOI":"10.1073\/pnas.0805817105","type":"journal-article","created":{"date-parts":[[2008,12,4]],"date-time":"2008-12-04T21:49:31Z","timestamp":1228427371000},"page":"19898-19903","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":96,"title":["Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy"],"prefix":"10.1073","volume":"105","author":[{"given":"Jonathan E.","family":"Sears","sequence":"first","affiliation":[{"name":"Departments of aOphthalmic Research and"},{"name":"Cell Biology, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland OH 44195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Departments of aOphthalmic Research and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quteba","family":"Ebrahem","sequence":"additional","affiliation":[{"name":"Departments of aOphthalmic Research and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bela","family":"Anand-Apte","sequence":"additional","affiliation":[{"name":"Departments of aOphthalmic Research and"},{"name":"Cell Biology, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland OH 44195"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2008,12,16]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1095-1024"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140419009"},{"key":"e_1_3_3_3_2","first-page":"345","article-title":"Neutralizing antibody to VEGF reduces intravitreous neovascularization and may not interfere with ongoing intraretinal vascularization in a rat model of retinopathy of prematurity","volume":"14","author":"Geisen P","year":"2008","unstructured":"P Geisen, et al., Neutralizing antibody to VEGF reduces intravitreous neovascularization and may not interfere with ongoing intraretinal vascularization in a rat model of retinopathy of prematurity. 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