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These studies demonstrate the two proteins are required for the same cellular differentiation events and are needed for normal calcium fluxes in the embryo. SepN is physically associated with RyRs and functions as a modifier of the RyR channel. In the absence of SepN, ryanodine receptors from zebrafish embryos or human diseased muscle have altered biochemical properties and have lost their normal sensitivity to redox conditions, which likely accounts for why mutations affecting either factor lead to similar diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0806015105","type":"journal-article","created":{"date-parts":[[2008,8,19]],"date-time":"2008-08-19T23:52:10Z","timestamp":1219189930000},"page":"12485-12490","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":189,"title":["Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle"],"prefix":"10.1073","volume":"105","author":[{"given":"Michael J.","family":"Jurynec","sequence":"first","affiliation":[{"name":"Departments of *Human Genetics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruohong","family":"Xia","sequence":"additional","affiliation":[{"name":"Physics Department, Eastern China Normal University, Shanghai 200062, China;"},{"name":"Physics Department, Portland State University, Portland, OR 97207;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Mackrill","sequence":"additional","affiliation":[{"name":"Department of Physiology, BioSciences Institute, University College Cork, Cork 30, Ireland; 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