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The structure of HA in complex with a known inhibitor of membrane fusion and virus infectivity,\n                    <jats:italic>tert<\/jats:italic>\n                    -butyl hydroquinone (TBHQ), shows that the inhibitor binds in a hydrophobic pocket formed at an interface between HA monomers. Occupation of this site by TBHQ stabilizes the neutral pH structure through intersubunit and intrasubunit interactions that presumably inhibit the conformational rearrangements required for membrane fusion. 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