{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:54:00Z","timestamp":1790636040598,"version":"4.1.0"},"reference-count":35,"publisher":"National Academy of Sciences","issue":"42","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2008,10,21]]},"abstract":"<jats:p>\n                    T20 (generic name: Enfuvirtide, brand name: Fuzeon) is the only FDA-approved HIV fusion inhibitor that is being used for treatment of HIV\/AIDS patients who have failed to respond to current antiretroviral drugs. However, it rapidly induces drug resistance\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . On the basis of the structural and functional information of anti-HIV peptides from a previous study, we designed an HIV fusion inhibitor named CP32M, a 32-mer synthetic peptide that is highly effective in inhibiting infection by a wide range of primary HIV-1 isolates from multiple genotypes with R5- or dual-tropic (R5X4) phenotype, including a group O virus (BCF02) that is resistant to T20 and C34 (another anti-HIV peptide). Strikingly, CP32M is exceptionally potent (at low picomolar level) against infection by a panel of HIV-1 mutants highly resistant to T20 and C34. These findings suggest that CP32M can be further developed as an antiviral therapeutic against multidrug resistant HIV-1.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0807335105","type":"journal-article","created":{"date-parts":[[2008,10,13]],"date-time":"2008-10-13T20:54:14Z","timestamp":1223931254000},"page":"16332-16337","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":126,"title":["Potent HIV fusion inhibitors against Enfuvirtide-resistant HIV-1 strains"],"prefix":"10.1073","volume":"105","author":[{"given":"Yuxian","family":"He","sequence":"first","affiliation":[{"name":"*Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065;"},{"name":"Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Chinese Academy of Military Medical Sciences, Beijing 100071, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Lu","sequence":"additional","affiliation":[{"name":"*Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[{"name":"*Lindsley F. 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