{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:36:47Z","timestamp":1791599807942,"version":"4.3.4"},"reference-count":47,"publisher":"National Academy of Sciences","issue":"41","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2008,10,14]]},"abstract":"<jats:p>\n                    Frontotemporal dementia (FTD) is characterized by cognitive and behavioral changes and, in a significant subset of patients, Parkinsonism. Histopathologically, FTD frequently presents with tau-containing lesions, which in familial cases result from mutations in the\n                    <jats:italic>MAPT<\/jats:italic>\n                    gene encoding tau. Here we present a novel transgenic mouse strain (K3) that expresses human tau carrying the FTD mutation K369I. K3 mice develop a progressive histopathology that is reminiscent of that in human FTD with the K369I mutation. In addition, K3 mice show early-onset memory impairment and amyotrophy in the absence of overt neurodegeneration. Different from our previously generated tau transgenic strains, the K3 mice express the transgene in the substantia nigra (SN) and show an early-onset motor phenotype that reproduces Parkinsonism with tremor, bradykinesia, abnormal gait, and postural instability. Interestingly, motor performance of young, but not old, K3 mice improves upon L-dopa treatment, which bears similarities to Parkinsonism in FTD. The early-onset symptoms in the K3 mice are mechanistically related to selectively impaired anterograde axonal transport of distinct cargos, which precedes the loss of dopaminergic SN neurons that occurs in aged mice. The impaired axonal transport in SN neurons affects, among others, vesicles containing the dopamine-synthesizing enzyme tyrosine hydroxylase. Distinct modes of transport are also impaired in sciatic nerves, which may explain amyotrophy. Together, the K3 mice are a unique model of FTD-associated Parkinsonism, with pathomechanistic implications for the human pathologic process.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0808084105","type":"journal-article","created":{"date-parts":[[2008,10,2]],"date-time":"2008-10-02T20:25:36Z","timestamp":1222979136000},"page":"15997-16002","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":204,"title":["Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia"],"prefix":"10.1073","volume":"105","author":[{"given":"Lars M.","family":"Ittner","sequence":"first","affiliation":[{"name":"*Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fath","sequence":"additional","affiliation":[{"name":"Oncology Research Unit, Children's Hospital at Westmead, Westmead, NSW 2145, Australia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazi D.","family":"Ke","sequence":"additional","affiliation":[{"name":"*Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian","family":"Bi","sequence":"additional","affiliation":[{"name":"*Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"van Eersel","sequence":"additional","affiliation":[{"name":"*Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kong M.","family":"Li","sequence":"additional","affiliation":[{"name":"LC Laboratory, Discipline of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Gunning","sequence":"additional","affiliation":[{"name":"Oncology Research Unit, Children's Hospital at Westmead, Westmead, NSW 2145, Australia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"G\u00f6tz","sequence":"additional","affiliation":[{"name":"*Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2008,10,14]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2194"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05016"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05017"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2420"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0796-783"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.11.4051"},{"key":"e_1_3_3_7_2","first-page":"1388","article-title":"Widespread cytoskeletal pathology characterizes corticobasal degeneration","volume":"146","author":"Feany MB","year":"1995","unstructured":"MB Feany, DW Dickson, Widespread cytoskeletal pathology characterizes corticobasal degeneration. 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