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It has been suggested that IEL are regulated through the interaction of the CD8\u03b1\u03b1 homodimer with the thymus leukemia (TL) antigen expressed by intestinal epithelial cells. We have generated and characterized mice genetically-deficient in TL expression. Our findings show that TL expression has a critical role in maintaining IEL effector functions. Also, TL deficiency accelerated colitis in a genetic model of inflammatory bowel disease. These findings reveal an important regulatory role of TL in controlling IEL function and intestinal inflammation.<\/jats:p>","DOI":"10.1073\/pnas.0808242105","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T20:58:35Z","timestamp":1226523515000},"page":"17931-17936","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":60,"title":["Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease"],"prefix":"10.1073","volume":"105","author":[{"given":"Danyvid","family":"Olivares-Villag\u00f3mez","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanice V.","family":"Mendez-Fernandez","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vrajesh V.","family":"Parekh","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saif","family":"Lalani","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffaney L.","family":"Vincent","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"Cheroutre","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Van Kaer","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2008,11,18]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104522"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5357.1737"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7973709"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.212290499"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00284-4"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1070"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00471.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/201779a0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.1.213"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.24.9727"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00027-X"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.10.5708"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.6.3501"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.8.3881"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063564"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.5.1131"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxg131"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/310650a0"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/3.6.563"},{"key":"e_1_3_3_20_2","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.4049\/jimmunol.150.6.2179","article-title":"Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals","volume":"150","author":"Sydora BC","year":"1993","unstructured":"BC Sydora, et al., Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals. 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