{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:03:44Z","timestamp":1791349424122,"version":"4.3.1"},"reference-count":40,"publisher":"National Academy of Sciences","issue":"10","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2009,3,10]]},"abstract":"<jats:p>Plasma cells represent the end stage of B-cell development and play a key role in providing an efficient antibody response, but they are also involved in numerous pathologies. Here we show that CD93, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93\/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts\/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. T-independent and T-dependent stimuli led to re-expression of CD93 via 2 pathways, either before or after CD138 or Blimp-1 expression. Strikingly, while humoral immune responses initially proceeded normally, CD93-deficient mice were unable to maintain antibody secretion and bone-marrow plasma-cell numbers, demonstrating that CD93 is important for the maintenance of plasma cells in bone marrow niches.<\/jats:p>","DOI":"10.1073\/pnas.0809736106","type":"journal-article","created":{"date-parts":[[2009,2,19]],"date-time":"2009-02-19T21:39:48Z","timestamp":1235079588000},"page":"3895-3900","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":141,"title":["CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche"],"prefix":"10.1073","volume":"106","author":[{"given":"St\u00e9phane","family":"Chevrier","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Genton","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Kallies","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Karnowski","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc A.","family":"Otten","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Malissen","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale\/Centre National de la Recherche Scientifique, Universit\u00e9 de la M\u00e9diterran\u00e9e, 13284 Marseille, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Malissen","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale\/Centre National de la Recherche Scientifique, Universit\u00e9 de la M\u00e9diterran\u00e9e, 13284 Marseille, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Botto","sequence":"additional","affiliation":[{"name":"Molecular Genetics and Rheumatology Section, Division of Medicine, Faculty of Medicine, Imperial College, Hammersmith Campus, London W12 0NN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn M.","family":"Corcoran","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Nutt","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Acha-Orbea","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2009,3,10]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115723"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830180221"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.3.1895-1902.1995"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/40540"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00267-X"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90321-2"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051611"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040973"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.04.007"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2204"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1886"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2507"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1440"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040719"},{"key":"e_1_3_3_15_2","doi-asserted-by":"crossref","first-page":"332","DOI":"10.4049\/jimmunol.132.1.332","article-title":"Cell surface antigens expressed by subsets of pre-B cells and B cells","volume":"132","author":"McKearn JP","year":"1984","unstructured":"JP McKearn, C Baum, JM Davie, Cell surface antigens expressed by subsets of pre-B cells and B cells. J Immunol 132, 332\u2013339 (1984).","journal-title":"J Immunol"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199811)28:11<3738::AID-IMMU3738>3.0.CO;2-Q"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.4.2285"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.3.551"},{"key":"e_1_3_3_19_2","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.4049\/jimmunol.162.5.2538","article-title":"B cell response after MMTV infection: extrafollicular plasmablasts represent the main infected population and can transmit viral infection","volume":"162","author":"Ardavin C","year":"1999","unstructured":"C Ardavin, et al., B cell response after MMTV infection: extrafollicular plasmablasts represent the main infected population and can transmit viral infection. J Immunol 162, 2538\u20132545 (1999).","journal-title":"J Immunol"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1572"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5312.589"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.01.012"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3109\/08830180109056723"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031571"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.6.3406"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1313.014"},{"key":"e_1_3_3_27_2","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.4049\/jimmunol.162.6.3583","article-title":"C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity","volume":"162","author":"Nepomuceno RR","year":"1999","unstructured":"RR Nepomuceno, S Ruiz, M Park, AJ Tenner, C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity. J Immunol 162, 3583\u20133589 (1999).","journal-title":"J Immunol"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80419-7"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00335-7"},{"key":"e_1_3_3_30_2","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.4049\/jimmunol.152.8.4005","article-title":"Cell-surface protein identified on phagocytic cells modulates the C1q-mediated enhancement of phagocytosis","volume":"152","author":"Guan E","year":"1994","unstructured":"E Guan, SL Robinson, EB Goodman, AJ Tenner, Cell-surface protein identified on phagocytic cells modulates the C1q-mediated enhancement of phagocytosis. J Immunol 152, 4005\u20134016 (1994).","journal-title":"J Immunol"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.10.5222"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2005.02120.x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.49.34507"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110694200"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069057"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80637-8"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)80054-I"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200105)31:5<1370::AID-IMMU1370>3.0.CO;2-B"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.3.1150"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-2-r19"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.0809736106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T23:08:14Z","timestamp":1684883294000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.0809736106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,10]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,3,10]]}},"alternative-id":["10.1073\/pnas.0809736106"],"URL":"https:\/\/doi.org\/10.1073\/pnas.0809736106","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,10]]},"assertion":[{"value":"2008-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-03-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}