{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:56:49Z","timestamp":1791421009357,"version":"4.3.3"},"reference-count":55,"publisher":"National Academy of Sciences","issue":"8","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,4,10]]},"abstract":"<jats:p>In adult rodents, neural progenitor cells in the subependymal (SZ)\n zone of the lateral cerebral ventricle generate neuroblasts that\n migrate in chains via the rostral migratory stream (RMS) into the\n olfactory bulb (OB), where they differentiate into interneurons.\n However, the existence of this neurogenic migratory system in other\n mammals has remained unknown. Here, we report the presence of a\n homologue of the rodent SZ\/RMS in the adult macaque monkey, a\n nonhuman Old World primate with a relatively smaller OB. Our\n results\u2014obtained by using combined immunohistochemical detection of a\n marker for DNA replication (5-bromodeoxyuridine) and several cell\n type-specific markers\u2014indicate that dividing cells in the adult monkey\n SZ generate neuroblasts that undergo restricted chain migration over an\n extended distance of more than 2 cm to the OB and differentiate into\n granule interneurons. These findings in a nonhuman primate extend and\n support the use of the SZ\/RMS as a model system for studying neural\n regenerative mechanisms in the human brain.<\/jats:p>","DOI":"10.1073\/pnas.081074998","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:44:19Z","timestamp":1027680259000},"page":"4752-4757","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":361,"title":["The generation, migration, and differentiation of olfactory neurons in the adult primate brain"],"prefix":"10.1073","volume":"98","author":[{"given":"David R.","family":"Kornack","sequence":"first","affiliation":[{"name":"Center for Aging and Developmental Biology, Department of\r Neurobiology and Anatomy, University of Rochester Medical Center,\r Rochester, NY 14642; and Section of Neurobiology, Yale\r University School of Medicine, New Haven, CT 06510"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasko","family":"Rakic","sequence":"additional","affiliation":[{"name":"Center for Aging and Developmental Biology, Department of\r Neurobiology and Anatomy, University of Rochester Medical Center,\r Rochester, NY 14642; and Section of Neurobiology, Yale\r University School of Medicine, New Haven, CT 06510"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2001,4,10]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-4954-0"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.887941"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7079742"},{"key":"e_1_3_3_4_2","first-page":"399","volume":"72","author":"Stanfield B B","year":"1988","unstructured":"B B Stanfield, J E Trice Exp Brain Res 72, 399\u2013406 (1988).","journal-title":"Exp Brain Res"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901370404"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90748-A"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8178174"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(97)01191-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)80017-8"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.25.14895"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5251.978"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01939380"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80317-7"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90281-U"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1823"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900710108"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/3305"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.10.5768"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000006668"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01416-2"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/35039559"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01190834"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.3.1242"},{"key":"e_1_3_3_24_2","unstructured":"Rakic P. 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