{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:47:29Z","timestamp":1790905649634,"version":"4.1.0"},"reference-count":30,"publisher":"National Academy of Sciences","issue":"9","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,4,24]]},"abstract":"<jats:p>\n                    A member of a\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    receptor family for\n erythrocyte invasion was identified on chromosome 13 from the\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    genome sequence of the Sanger\n Centre (Cambridge, U.K.). The protein (named BAEBL) has homology to\n EBA-175, a\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    receptor that binds\n specifically to sialic acid and the peptide backbone of glycophorin A\n on erythrocytes. Both EBA-175 and BAEBL localize to the micronemes,\n organelles at the invasive ends of the parasites that contain other\n members of the family. Like EBA-175, the erythrocyte receptor for BAEBL\n is destroyed by neuraminidase and trypsin, indicating that the\n erythrocyte receptor is a sialoglycoprotein. Its specificity, however,\n differs from that of EBA-175 in that BAEBL can bind to erythrocytes\n that lack glycophorin A, the receptor for EBA-175. It has reduced\n binding to erythrocytes with the Gerbich mutation found in another\n erythrocyte, sialoglycoprotein (glycophorin C\/D). The interest in\n BAEBL's reduced binding to Gerbich erythrocytes derives from the high\n frequency of the Gerbich phenotype in some regions of Papua New Guinea\n where\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    is hyperendemic.\n                  <\/jats:p>","DOI":"10.1073\/pnas.081075398","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:44:19Z","timestamp":1027680259000},"page":"5222-5227","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":151,"title":["Characterization of a\n                    <i>Plasmodium falciparum<\/i>\n                    erythrocyte-binding protein paralogous to EBA-175"],"prefix":"10.1073","volume":"98","author":[{"given":"D. C. Ghislaine","family":"Mayer","sequence":"first","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy\r and Infectious Diseases, National Institutes of Health, 4 Center Drive,\r Room 4\/126, Bethesda, MD 20892-0425; Department of\r Molecular Parasitology, Ehime University School of Medicine,\r Shigenobu-cho, Ehime 791-0295, Japan; and\r Immunohematology Laboratory, New York Blood Center, 310\r East 67th Street, New York, NY 10021-4295"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy\r and Infectious Diseases, National Institutes of Health, 4 Center Drive,\r Room 4\/126, Bethesda, MD 20892-0425; Department of\r Molecular Parasitology, Ehime University School of Medicine,\r Shigenobu-cho, Ehime 791-0295, Japan; and\r Immunohematology Laboratory, New York Blood Center, 310\r East 67th Street, New York, NY 10021-4295"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana E.","family":"Hudson-Taylor","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy\r and Infectious Diseases, National Institutes of Health, 4 Center Drive,\r Room 4\/126, Bethesda, MD 20892-0425; Department of\r Molecular Parasitology, Ehime University School of Medicine,\r Shigenobu-cho, Ehime 791-0295, Japan; and\r Immunohematology Laboratory, New York Blood Center, 310\r East 67th Street, New York, NY 10021-4295"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion E.","family":"Reid","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy\r and Infectious Diseases, National Institutes of Health, 4 Center Drive,\r Room 4\/126, Bethesda, MD 20892-0425; Department of\r Molecular Parasitology, Ehime University School of Medicine,\r Shigenobu-cho, Ehime 791-0295, Japan; and\r Immunohematology Laboratory, New York Blood Center, 310\r East 67th Street, New York, NY 10021-4295"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis H.","family":"Miller","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy\r and Infectious Diseases, National Institutes of Health, 4 Center Drive,\r Room 4\/126, Bethesda, MD 20892-0425; Department of\r Molecular Parasitology, Ehime University School of Medicine,\r Shigenobu-cho, Ehime 791-0295, Japan; and\r Immunohematology Laboratory, New York Blood Center, 310\r East 67th Street, New York, NY 10021-4295"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2001,4,17]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1126\/science.803712","volume":"187","author":"Dvorak J A","year":"1975","unstructured":"J A Dvorak, L H Miller, W C Whitehouse, T Shiroishi Science 187, 748\u2013750 (1975).","journal-title":"Science"},{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1083\/jcb.77.1.72","volume":"77","author":"Aikawa M","year":"1978","unstructured":"M Aikawa, L H Miller, J Johnson, J Rabbege J Cell Biol 77, 72\u201382 (1978).","journal-title":"J Cell Biol"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1126\/science.3901257","volume":"230","author":"Camus D","year":"1985","unstructured":"D Camus, T H Hadley Science 230, 553\u2013556 (1985).","journal-title":"Science"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1084\/jem.167.6.1873","volume":"167","author":"Haynes J D","year":"1988","unstructured":"J D Haynes, J P Dalton, F W Klotz, M H McGinnis, T J Hadley, D E Hudson J Exp Med 167, 1873\u20131881 (1988).","journal-title":"J Exp Med"},{"key":"e_1_3_3_5_2","first-page":"142","volume":"63","author":"Adams J H","year":"1990","unstructured":"J H Adams, D H Hudson, M Torii, G E Ward, T E Wellems, M Aikawa Cell 63, 142\u2013153 (1990).","journal-title":"Cell"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1083\/jcb.111.5.1877","volume":"111","author":"Sim B K L","year":"1990","unstructured":"B K L Sim, P A Orlandi, J D Haynes, F W Klotz, J M Carter, D Camus J Cell Biol 111, 1877\u20131884 (1990).","journal-title":"J Cell Biol"},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/0092-8674(92)90642-P","volume":"69","author":"Galinski M R","year":"1992","unstructured":"M R Galinski, C C Medina, P Ingravallo, J W Barnwell Cell 69, 1213\u20131226 (1992).","journal-title":"Cell"},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"7085","DOI":"10.1073\/pnas.89.15.7085","volume":"89","author":"Adams J H","year":"1992","unstructured":"J H Adams, B K L Sim, S A Dolan, X Fang, D C Kaslow, L H Miller Proc Natl Acad Sci USA 89, 7085\u20137089 (1992).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1056\/NEJM197608052950602","volume":"295","author":"Miller L H","year":"1976","unstructured":"L H Miller, S J Mason, D F Clyde, M H McGinniss N Engl J Med 295, 302\u2013304 (1976).","journal-title":"N Engl J Med"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1084\/jem.149.1.172","volume":"149","author":"Miller L H","year":"1979","unstructured":"L H Miller, M Aikawa, J G Johnson, T Shiroishi J Exp Med 149, 172\u2013184 (1979).","journal-title":"J Exp Med"},{"key":"e_1_3_3_11_2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1084\/jem.180.2.497","volume":"180","author":"Chitnis C E","year":"1994","unstructured":"C E Chitnis, L H Miller J Exp Med 180, 497\u2013506 (1994).","journal-title":"J Exp Med"},{"key":"e_1_3_3_12_2","doi-asserted-by":"crossref","first-page":"14067","DOI":"10.1073\/pnas.96.24.14067","volume":"96","author":"Ranjan A","year":"1999","unstructured":"A Ranjan, C E Chitnis Proc Natl Acad Sci USA 96, 14067\u201314072 (1999).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_3_13_2","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1084\/jem.138.6.1597","volume":"138","author":"Miller L H","year":"1973","unstructured":"L H Miller, J A Dvorak, T Shiroishi, J R Durocher J Exp Med 138, 1597\u20131601 (1973).","journal-title":"J Exp Med"},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1126\/science.8009226","volume":"264","author":"Sim B K L","year":"1994","unstructured":"B K L Sim, C E Chitnis, K Wasniowska, T J Hadley, L H Miller Science 264, 1941\u20131944 (1994).","journal-title":"Science"},{"key":"e_1_3_3_15_2","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1172\/JCI114753","volume":"86","author":"Dolan S A","year":"1990","unstructured":"S A Dolan, L H Miller, T E Wellems J Clin Invest 86, 618\u2013624 (1990).","journal-title":"J Clin Invest"},{"key":"e_1_3_3_16_2","unstructured":"Adams J. 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