{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:33:08Z","timestamp":1781105588909,"version":"3.54.1"},"reference-count":34,"publisher":"National Academy of Sciences","issue":"7","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,3,27]]},"DOI":"10.1073\/pnas.081082498","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:44:19Z","timestamp":1027680259000},"page":"3641-3643","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":46,"title":["Uncoupling fibroblast growth factor receptor 2 ligand binding specificity leads to Apert syndrome-like phenotypes"],"prefix":"10.1073","volume":"98","author":[{"given":"Kai","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Pharmacology, Washington\r University Medical School, Campus Box 8103, 660 South Euclid\r Avenue, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Ornitz","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Pharmacology, Washington\r University Medical School, Campus Box 8103, 660 South Euclid\r Avenue, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2001,3,27]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.2741\/A321"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(00)89088-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(95)00102-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071586898"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)60149-7"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2001-2-3-reviews3005"},{"key":"e_1_3_2_7_2","first-page":"1","volume":"60","author":"Johnson D E","year":"1993","unstructured":"D E Johnson, L T Williams Adv Cancer Res 60, 1\u201341 (1993).","journal-title":"Adv Cancer Res"},{"key":"e_1_3_2_8_2","first-page":"240","volume":"12","author":"Ornitz D M","year":"1992","unstructured":"D M Ornitz, A Yayon, J G Flanagan, C M Svahn, E Levi, P Leder Mol Cell Biol 12, 240\u2013247 (1992).","journal-title":"Mol Cell Biol"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6603(08)61031-4"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(200002)22:2<108::AID-BIES2>3.0.CO;2-M"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/302245"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.26.14536"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.1.246"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.25.15292"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00034-9"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.21.13230"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.11.1571"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/82609"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/75644"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/82601"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.5.989"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.9.5082"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.4.753"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.3.483"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3721"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.20.3156"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/5096"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0295-165"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4773(94)90050-7"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.114.1.233"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.113.4.1419"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(98)00133-6"},{"key":"e_1_3_2_33_2","first-page":"316","volume-title":"Craniosynostosis, Diagnosis, Evaluation, and Management","author":"Cohen M M J","year":"2000","unstructured":"M M J Cohen Craniosynostosis, Diagnosis, Evaluation, and Management, eds M M J Cohen, R E MacLean (Oxford Univ. Press, New York), pp. 316\u2013353 (2000)."},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.15.7894"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.081082498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T17:10:00Z","timestamp":1649783400000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.081082498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3,27]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2001,3,27]]}},"alternative-id":["10.1073\/pnas.081082498"],"URL":"https:\/\/doi.org\/10.1073\/pnas.081082498","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3,27]]},"assertion":[{"value":"2001-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}