{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:14:01Z","timestamp":1790874841619,"version":"4.1.0"},"reference-count":28,"publisher":"National Academy of Sciences","issue":"18","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2009,5,5]]},"abstract":"<jats:p>\n                    The possibility that V\u03b32V\u03b42 T effector cells can confer protection against pulmonary infectious diseases has not been tested. We have recently demonstrated that single-dose (\n                    <jats:italic>E<\/jats:italic>\n                    )-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) plus IL-2 treatment can induce prolonged accumulation of V\u03b32V\u03b42 T effector cells in lungs. Here, we show that a delayed HMBPP\/IL-2 administration after inhalational\n                    <jats:italic>Yersinia pestis<\/jats:italic>\n                    infection induced marked expansion of V\u03b32V\u03b42 T cells but failed to control extracellular plague bacterial replication\/infection. Surprisingly, despite the absence of infection control, expansion of V\u03b32V\u03b42 T cells after HMBPP\/IL-2 treatment led to the attenuation of inhalation plague lesions in lungs. Consistently, HMBPP-activated V\u03b32V\u03b42 T cells accumulated and localized in pulmonary interstitials surrounding small blood vessels and airway mucosa in the lung tissues with no or mild plague lesions. These infiltrating V\u03b32V\u03b42 T cells produced FGF-7, a homeostatic mediator against tissue damages. In contrast, control macaques treated with glucose plus IL-2 or glucose alone exhibited severe hemorrhages and necrosis in most lung lobes, with no or very few V\u03b32V\u03b42 T cells detectable in lung tissues. The findings are consist with the paradigm that circulating V\u03b32V\u03b42 T cells can traffic to lungs for homeostatic protection against tissue damages in infection.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0811250106","type":"journal-article","created":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T22:34:59Z","timestamp":1240353299000},"page":"7553-7558","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":43,"title":["Antigen-specific V\u03b32V\u03b42 T effector cells confer homeostatic protection against pneumonic plaque lesions"],"prefix":"10.1073","volume":"106","author":[{"given":"Dan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, IL 60612;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, IL 60612;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahida","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, IL 60612;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, IL 60612;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 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