{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:25:02Z","timestamp":1791159902146,"version":"4.1.0"},"reference-count":48,"publisher":"National Academy of Sciences","issue":"19","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2009,5,12]]},"abstract":"<jats:p>\n                    Little is known about prostaglandin F\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    in cardiovascular homeostasis. Prostaglandin F\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    dose-dependently elevates blood pressure in WT mice via activation of the F prostanoid (FP) receptor. The FP is expressed in preglomerular arterioles, renal collecting ducts, and the hypothalamus. Deletion of the FP reduces blood pressure, coincident with a reduction in plasma renin concentration, angiotensin, and aldosterone, despite a compensatory up-regulation of AT1 receptors and an augmented hypertensive response to infused angiotensin II. Plasma and urinary osmolality are decreased in FP KOs that exhibit mild polyuria and polydipsia. Atherogenesis is retarded by deletion of the FP, despite the absence of detectable receptor expression in aorta or in atherosclerotic lesions in Ldlr KOs. Although vascular TNF\n                    <jats:sub>\u03b1<\/jats:sub>\n                    , inducible nitric oxide enzyme and TGF\n                    <jats:sub>\u03b2<\/jats:sub>\n                    are reduced and lesional macrophages are depleted in the FP\/Ldlr double KOs, this result reflects the reduction in lesion burden, as the FP is not expressed on macrophages and its deletion does not alter macrophage cytokine generation. Blockade of the FP offers an approach to the treatment of hypertension and its attendant systemic vascular disease.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0811834106","type":"journal-article","created":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T20:54:18Z","timestamp":1240606458000},"page":"7985-7990","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":104,"title":["Prostaglandin F\n                    <sub>2\u03b1<\/sub>\n                    elevates blood pressure and promotes atherosclerosis"],"prefix":"10.1073","volume":"106","author":[{"given":"Ying","family":"Yu","sequence":"first","affiliation":[{"name":"Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret B.","family":"Lucitt","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Stubbe","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla G.","family":"Friis","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, University of Southern Denmark-Odense, DK-5000 Odense C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille B.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, University of Southern Denmark-Odense, DK-5000 Odense C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boye L.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, University of Southern Denmark-Odense, DK-5000 Odense C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emer M.","family":"Smyth","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garret A.","family":"FitzGerald","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2009,5,12]]},"reference":[{"key":"e_1_3_3_1_2","volume-title":"Textbook of Hypertension","author":"Swales J","year":"1994","unstructured":"J Swales Textbook of Hypertension (Blackwell Scientific, Boston, 1994)."},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.74.6.1141"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.11.046"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8376"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.110932"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16044"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214752"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00219.2004"},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0022-3565(25)32371-2","article-title":"6-Keto-prostaglandin E1 is more potent than prostaglandin I2 as a renal vasodilator and renin secretagogue","volume":"216","author":"Jackson EK","year":"1981","unstructured":"EK Jackson, et al., 6-Keto-prostaglandin E1 is more potent than prostaglandin I2 as a renal vasodilator and renin secretagogue. 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