{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:50:58Z","timestamp":1793166658549,"version":"4.5.0"},"reference-count":41,"publisher":"National Academy of Sciences","issue":"14","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2009,4,7]]},"abstract":"<jats:p>Implantation is crucial for placental development that will subsequently impact fetal growth and pregnancy success with consequences on postnatal health. We postulated that the pattern of genes expressed by the endometrium when the embryo becomes attached to the mother uterus could account for the final outcome of a pregnancy. As a model, we used the bovine species where the embryo becomes progressively and permanently attached to the endometrium from day 20 of gestation onwards. At that stage, we compared the endometrial genes profiles in the presence of an in vivo fertilized embryo (AI) with the endometrial patterns obtained in the presence of nuclear transfer (SCNT) or in vitro fertilized embryos (IVF), both displaying lower and different potentials for term development. Our data provide evidence that the endometrium can be considered as a biological sensor able to fine-tune its physiology in response to the presence of embryos whose development will become altered much later after the implantation process. Compared with AI, numerous biological functions and several canonical pathways with a major impact on metabolism and immune function were found to be significantly altered in the endometrium of SCNT pregnancies at implantation, whereas the differences were less pronounced with IVF embryos. Determining the limits of the endometrial plasticity at the onset of implantation should bring new insights on the contribution of the maternal environment to the development of an embryo and the success of pregnancy.<\/jats:p>","DOI":"10.1073\/pnas.0812722106","type":"journal-article","created":{"date-parts":[[2009,3,18]],"date-time":"2009-03-18T21:49:37Z","timestamp":1237412977000},"page":"5687-5692","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":215,"title":["Endometrium as an early sensor of in vitro embryo manipulation technologies"],"prefix":"10.1073","volume":"106","author":[{"given":"Nad\u00e9ra","family":"Mansouri-Attia","sequence":"first","affiliation":[{"name":"Institut National de la Recherche Agronomique, Unit\u00e9 Mixte de Recherche 1198 Biologie du D\u00e9veloppement et Reproduction, F-78352 Jouy-en-Josas, France; Centre National de la Recherche Scientifique, F-78352 Jouy-en-Josas, France; \u00c9cole Nationale V\u00e9t\u00e9rinaire d'Alfort, F-94704 Maisons Alfort, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Sandra","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique, Unit\u00e9 Mixte de Recherche 1198 Biologie du D\u00e9veloppement et Reproduction, F-78352 Jouy-en-Josas, France; Centre National de la Recherche Scientifique, F-78352 Jouy-en-Josas, France; \u00c9cole Nationale V\u00e9t\u00e9rinaire d'Alfort, F-94704 Maisons Alfort, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Aubert","sequence":"additional","affiliation":[{"name":"UMR Math\u00e9matiques Informatique Appliqu\u00e9es, AgroParisTech-Institut National de la Recherche Agronomique, 75231 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Degrelle","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique, Unit\u00e9 Mixte de Recherche 1198 Biologie du D\u00e9veloppement et Reproduction, F-78352 Jouy-en-Josas, France; Centre National de la Recherche Scientifique, F-78352 Jouy-en-Josas, France; \u00c9cole Nationale V\u00e9t\u00e9rinaire d'Alfort, F-94704 Maisons Alfort, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin E.","family":"Everts","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Giraud-Delville","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique, Unit\u00e9 Mixte de Recherche 1198 Biologie du D\u00e9veloppement et Reproduction, F-78352 Jouy-en-Josas, France; Centre National de la Recherche Scientifique, F-78352 Jouy-en-Josas, France; \u00c9cole Nationale V\u00e9t\u00e9rinaire d'Alfort, F-94704 Maisons Alfort, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvan","family":"Heyman","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique, Unit\u00e9 Mixte de Recherche 1198 Biologie du D\u00e9veloppement et Reproduction, F-78352 Jouy-en-Josas, France; Centre National de la Recherche Scientifique, F-78352 Jouy-en-Josas, France; \u00c9cole Nationale V\u00e9t\u00e9rinaire d'Alfort, F-94704 Maisons Alfort, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Galio","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique, Unit\u00e9 G\u00e9nomique et Physiologie de la Lactation, Jouy-en-Josas, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Hue","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique, Unit\u00e9 Mixte de Recherche 1198 Biologie du D\u00e9veloppement et Reproduction, F-78352 Jouy-en-Josas, France; Centre National de la Recherche Scientifique, F-78352 Jouy-en-Josas, France; \u00c9cole Nationale V\u00e9t\u00e9rinaire d'Alfort, F-94704 Maisons Alfort, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzhong","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Regenerative Biology\/Department of Animal Sciences, Storrs, CT 06269"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. Cindy","family":"Tian","sequence":"additional","affiliation":[{"name":"Center for Regenerative Biology\/Department of Animal Sciences, Storrs, CT 06269"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harris A.","family":"Lewin","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Renard","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique, Unit\u00e9 Mixte de Recherche 1198 Biologie du D\u00e9veloppement et Reproduction, F-78352 Jouy-en-Josas, France; Centre National de la Recherche Scientifique, F-78352 Jouy-en-Josas, France; \u00c9cole Nationale V\u00e9t\u00e9rinaire d'Alfort, F-94704 Maisons Alfort, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2009,4,7]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(01)00645-8"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00398"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.104.030957"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1042954"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.106.051581"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.004481"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508952102"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.20927"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.20345"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00223.2007"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2007.00519_6.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1677\/jme.1.02009"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00996"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.03.006"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0268"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod63.6.1787"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod30.3.763"},{"key":"e_1_3_3_18_2","first-page":"85","article-title":"Sheep uterine gland knockout (UGKO) model","volume":"121","author":"Spencer TE","year":"2006","unstructured":"TE Spencer, CA Gray, Sheep uterine gland knockout (UGKO) model. Methods Mol Med 121, 85\u201394 (2006).","journal-title":"Methods Mol Med"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.1207"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/09513590701350291"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/clo.2007.0019"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01451576"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401069101"},{"key":"e_1_3_3_24_2","first-page":"81","article-title":"Plac8 and Plac9, novel placental-enriched genes identified through microarray analysis","volume":"309","author":"Galaviz-Hernandez C","year":"2003","unstructured":"C Galaviz-Hernandez, et al., Plac8 and Plac9, novel placental-enriched genes identified through microarray analysis. Genes 309, 81\u201389 (2003).","journal-title":"Genes"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2004.02.006"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0321"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2006-492"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod67.1.55"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.11.010"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504468103"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod66.6.1596"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod66.1.6"},{"key":"e_1_3_3_33_2","first-page":"671","article-title":"Development of bovine embryos cultured in the serum free sequential media ISM1\/ISM2","volume":"57","author":"Heyman Y","year":"2002","unstructured":"Y Heyman, Y Lavergne, G Charpigny, JP Renard, Y Menezo, Development of bovine embryos cultured in the serum free sequential media ISM1\/ISM2. Theriogenology 57, 671 (2002).","journal-title":"Theriogenology"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.20870\/productions-animales.2005.18.5.3537"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.09.043"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00188.2007"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2005.02.003"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-98"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.4.e15"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti023"},{"key":"e_1_3_3_41_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini Y","year":"1995","unstructured":"Y Benjamini, Y Hochberg, Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Statist Soc B 57, 289\u2013300 (1995).","journal-title":"J R Statist Soc B"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.0812722106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T09:44:25Z","timestamp":1739007865000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.0812722106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,7]]},"references-count":41,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2009,4,7]]}},"alternative-id":["10.1073\/pnas.0812722106"],"URL":"https:\/\/doi.org\/10.1073\/pnas.0812722106","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1162369.622870","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,7]]},"assertion":[{"value":"2008-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-04-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}