{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:26:00Z","timestamp":1791267960494,"version":"4.1.0"},"reference-count":53,"publisher":"National Academy of Sciences","issue":"36","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2009,9,8]]},"abstract":"<jats:p>Besides the enormous medical and economic consequences, national disasters, such as the Wenchuan 8.0 earthquake, also pose a risk to the mental health of survivors. In this context, a better understanding is needed of how functional brain systems adapt to severe emotional stress. Previous animal studies have demonstrated the importance of limbic, paralimbic, striatal, and prefrontal structures in stress and fear responses. Human studies, which have focused primarily on patients with clinically established posttraumatic stress disorders, have reported abnormalities in similar brain structures. At present, little is known about potential alterations of brain function in trauma survivors shortly after traumatic events. Here, we show alteration of brain function in a cohort of healthy survivors within 25 days after the Wenchuan earthquake by a recently discovered method known as \u201cresting-state\u201d functional MRI. The current investigation demonstrates that regional activity in frontolimbic and striatal areas increased significantly and connectivity among limbic and striatal networks was attenuated in our participants who had recently experienced severe emotional trauma. Trauma victims also had a reduced temporal synchronization within the \u201cdefault mode\u201d of resting-state brain function, which has been characterized in humans and other species. Taken together, our findings provide evidence that significant alterations in brain function, similar in many ways to those observed in posttraumatic stress disorders, can be seen shortly after major traumatic experiences, highlighting the need for early evaluation and intervention for trauma survivors.<\/jats:p>","DOI":"10.1073\/pnas.0812751106","type":"journal-article","created":{"date-parts":[[2009,8,31]],"date-time":"2009-08-31T22:09:22Z","timestamp":1251756562000},"page":"15412-15417","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":124,"title":["High-field MRI reveals an acute impact on brain function in survivors of the magnitude 8.0 earthquake in China"],"prefix":"10.1073","volume":"106","author":[{"given":"Su","family":"Lui","sequence":"first","affiliation":[{"name":"Huaxi MR Research Center, Department of Radiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Huang","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center, Department of Radiology, and"},{"name":"Department of Psychiatry, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu 610041, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Chen","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center, Department of Radiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hehan","family":"Tang","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center, Department of Radiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tijiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center, Department of Radiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Li","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center, Department of Radiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongming","family":"Li","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center, Department of Radiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu 610041, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond C.","family":"Chan","sequence":"additional","affiliation":[{"name":"Institute of Psychology, Neuropsychology, and Applied Cognitive Neuroscience Laboratory, and Institute of Psychology, Key Laboratory of Mental Health, Chinese Academy of Sciences, Beijing 10001, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mechelli","sequence":"additional","affiliation":[{"name":"Section of Neuroimaging, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London SE5 8AF, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Center for Cognitive Medicine, University of Illinois, Chicago, IL 60612; 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