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Binding of the natural ligand\n dihydrotestosterone by the mutant LBD involves interactions with the\n same residues as in the wild-type receptor, with the exception of the\n side chain of threonine 877, which is an alanine residue in the mutant.\n This structural difference in the binding pocket can explain the\n ability of the mutant AR found in LNCaP cells (T877A) to accommodate\n progesterone and other ligands that the wild-type receptor cannot.<\/jats:p>","DOI":"10.1073\/pnas.081565498","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:44:19Z","timestamp":1027680259000},"page":"4904-4909","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":388,"title":["Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone"],"prefix":"10.1073","volume":"98","author":[{"given":"John S.","family":"Sack","sequence":"first","affiliation":[{"name":"Bristol\u2013Myers Squibb Pharmaceutical Research Institute, P.O. 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