{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:09:44Z","timestamp":1790770184564,"version":"4.1.0"},"reference-count":49,"publisher":"National Academy of Sciences","issue":"9","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2003,4,29]]},"abstract":"<jats:p>\n                    Mutations have been described in the ataxia telangiectasia mutated (\n                    <jats:italic>ATM<\/jats:italic>\n                    ) gene in small numbers of cases of lymphoid neoplasia. However, surveys of the\n                    <jats:italic>ATM<\/jats:italic>\n                    mutation status in lymphoma have been limited due to the large size (62 exons) and complex mutational spectrum of this gene. We have used microarray-based assays with 250,000 oligonucleotides to screen lymphomas from 120 patients for all possible\n                    <jats:italic>ATM<\/jats:italic>\n                    coding and splice junction mutations. The subtypes included were diffuse large B cell, mantle cell, immunoblastic large B cell, follicular, posttransplant lymphoproliferative disorder, and peripheral T cell lymphoma. We found the highest percentage of\n                    <jats:italic>ATM<\/jats:italic>\n                    mutations within the mantle cell (MCL) subtype (43%, 12 of 28 cases), followed by a lower level (10% of cases) in the other subtypes. A frame-shift\n                    <jats:italic>ATM<\/jats:italic>\n                    mutation was found in one peripheral T cell lymphoma patient. In six MCL cases examined, four\n                    <jats:italic>ATM<\/jats:italic>\n                    variants were due to somatic mutation in the tumor cells whereas two others seemed to be germ-line in origin. There was no difference in\n                    <jats:italic>p53<\/jats:italic>\n                    mutation status in the\n                    <jats:italic>ATM<\/jats:italic>\n                    mutant and wild-type groups of MCL. There was no statistically significant difference in the median overall survival of patients with wild-type vs. mutated\n                    <jats:italic>ATM<\/jats:italic>\n                    in MCL. Additional mutational and functional analyses are needed to determine whether\n                    <jats:italic>ATM<\/jats:italic>\n                    mutations contribute to the development and progression of MCL or are just the consequence of genomic instability in MCL.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0831102100","type":"journal-article","created":{"date-parts":[[2003,4,29]],"date-time":"2003-04-29T12:23:56Z","timestamp":1051619036000},"page":"5372-5377","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":83,"title":["Oligonucleotide microarrays demonstrate the highest frequency of\n                    <i>ATM<\/i>\n                    mutations in the mantle cell subtype of lymphoma"],"prefix":"10.1073","volume":"100","author":[{"given":"Nicole Y.","family":"Fang","sequence":"first","affiliation":[{"name":"Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD 20892; Departments of Pathology and Microbiology, Preventive and Societal Medicine, and Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198; and Institute for Genetic Medicine, University of Southern California, Los Angeles, CA 90089"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Greiner","sequence":"additional","affiliation":[{"name":"Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD 20892; Departments of Pathology and Microbiology, Preventive and Societal Medicine, and Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198; and Institute for Genetic Medicine, University of Southern California, Los Angeles, CA 90089"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis D.","family":"Weisenburger","sequence":"additional","affiliation":[{"name":"Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD 20892; Departments of Pathology and Microbiology, Preventive and Societal Medicine, and Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198; and Institute for Genetic Medicine, University of Southern California, Los Angeles, CA 90089"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing C.","family":"Chan","sequence":"additional","affiliation":[{"name":"Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD 20892; Departments of Pathology and Microbiology, Preventive and Societal Medicine, and Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198; and Institute for Genetic Medicine, University of Southern California, Los Angeles, CA 90089"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Vose","sequence":"additional","affiliation":[{"name":"Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD 20892; Departments of Pathology and Microbiology, Preventive and Societal Medicine, and Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198; and Institute for Genetic Medicine, University of Southern California, Los Angeles, CA 90089"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD 20892; Departments of Pathology and Microbiology, Preventive and Societal Medicine, and Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198; and Institute for Genetic Medicine, University of Southern California, Los Angeles, CA 90089"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James O.","family":"Armitage","sequence":"additional","affiliation":[{"name":"Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD 20892; Departments of Pathology and Microbiology, Preventive and Societal Medicine, and Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198; and Institute for Genetic Medicine, University of Southern California, Los Angeles, CA 90089"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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