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The MSC p43 protein was predominantly expressed in central neurons and interacted with NF light subunit in vivo. Mice lacking MSC p43 exhibited axon degeneration in motor neurons, defective neuromuscular junctions, muscular atrophy, and motor dysfunction. Furthermore, MSC p43 depletion in mice caused disorganization of the axonal NF network. Mechanistically, MSC p43 is required for maintaining normal phosphorylation levels of NFs. Thus, MSC p43 is indispensable in maintaining axonal integrity. Its dysfunction may underlie the NF disorganization and axon degeneration associated with motor neuron degenerative diseases.<\/jats:p>","DOI":"10.1073\/pnas.0901872106","type":"journal-article","created":{"date-parts":[[2009,8,26]],"date-time":"2009-08-26T22:23:42Z","timestamp":1251325422000},"page":"15944-15949","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":44,"title":["MSC p43 required for axonal development in motor neurons"],"prefix":"10.1073","volume":"106","author":[{"given":"Xiaodong","family":"Zhu","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, and"},{"name":"State Key Laboratory of Neuroscience Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Neuroscience Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Neuroscience Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiyun","family":"Shao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Neuroscience Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Neuroscience Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunghoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Medicinal Protein Network and Systems Biology, College of Pharmacy, Seoul National University, Seoul 151-742, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Neuroscience Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2009,9,15]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nrm2197","article-title":"Intermediate filaments: From cell architecture to nanomechanics","volume":"8","author":"Herrmann H","year":"2007","unstructured":"H Herrmann, H Bar, L Kreplak, SV Strelkov, U Aebi, Intermediate filaments: From cell architecture to nanomechanics. 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