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Sexual dimorphism in the reproductive tract is a product of M\u00fcllerian inhibiting substance (MIS), as well as the sex steroids. Males with a genetic deficiency in MIS signaling are sexually males, leading to the presumption that MIS is not a neural regulator. We challenge this presumption by reporting that most immature neurons in mice express the MIS-specific receptor (MISRII) and that male\n                    <jats:italic>Mis<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    and\n                    <jats:italic>Misrii<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice exhibit subtle feminization of their spinal motor neurons and of their exploratory behavior. Consequently, MIS may be a broad regulator of the subtle sex-linked biases in the nervous system.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0902253106","type":"journal-article","created":{"date-parts":[[2009,4,9]],"date-time":"2009-04-09T21:51:56Z","timestamp":1239313916000},"page":"7203-7208","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":62,"title":["M\u00fcllerian inhibiting substance contributes to sex-linked biases in the brain and behavior"],"prefix":"10.1073","volume":"106","author":[{"given":"Pei-Yu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anatomy, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Protheroe","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N.","family":"Clarkson","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floriane","family":"Imhoff","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Koishi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian S.","family":"McLennan","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2009,4,28]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1494"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(77)90270-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199507000-00013"},{"key":"e_1_3_3_4_2","first-page":"2724","article-title":"Profiling steroid hormones in amniotic fluid of midpregnancy by routine stable isotope dilution\/gas chromatography-mass spectrometry: Reference values and concentrations in fetuses at risk for 21-hydroxylase deficiency","volume":"84","author":"Wudy SA","year":"1999","unstructured":"SA Wudy, HG Dorr, C Solleder, M Djalali, J Homoki, Profiling steroid hormones in amniotic fluid of midpregnancy by routine stable isotope dilution\/gas chromatography-mass spectrometry: Reference values and concentrations in fetuses at risk for 21-hydroxylase deficiency. 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