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Here we show that conditional inactivation of \u03b2-\n                    <jats:italic>Catenin<\/jats:italic>\n                    (also termed\n                    <jats:italic>Ctnnb1<\/jats:italic>\n                    ) in foregut endoderm leads to absence of both the trachea and lung due to a failure in maintaining the respiratory fate. In converse, conditional expression of an activated form of \u03b2-\n                    <jats:italic>Catenin<\/jats:italic>\n                    leads to expansion of\n                    <jats:italic>Nkx2.1<\/jats:italic>\n                    , an early marker for the trachea and lung, into adjacent endoderm including the stomach epithelium. Analyses of these mutants show that the loss or gain of trachea\/lung progenitor identity is accompanied by an expansion or contraction of esophagus\/stomach progenitor identity, respectively. Our findings reveal an early role for \u03b2-\n                    <jats:italic>Catenin<\/jats:italic>\n                    in the establishment of respiratory progenitors in mouse foregut endoderm.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0902274106","type":"journal-article","created":{"date-parts":[[2009,9,9]],"date-time":"2009-09-09T20:46:55Z","timestamp":1252529215000},"page":"16287-16292","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":208,"title":["\u03b2-Catenin promotes respiratory progenitor identity in mouse foregut"],"prefix":"10.1073","volume":"106","author":[{"given":"Kelley S.","family":"Harris-Johnson","sequence":"first","affiliation":[{"name":"Laboratory of Genetics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric T.","family":"Domyan","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad M.","family":"Vezina","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Sun","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2009,9,22]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.1.60"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02310"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01570"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.06.015"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.23.4867"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.12.2695"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.3.483"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.20.3156"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/5096"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.006221"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(98)00393-X"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0729"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.015495"},{"key":"e_1_3_3_14_2","first-page":"873","article-title":"Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family","volume":"13","author":"Katoh M","year":"1996","unstructured":"M Katoh, M Hirai, T Sugimura, M Terada, Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family. 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