{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:16:34Z","timestamp":1791490594075,"version":"4.3.4"},"reference-count":46,"publisher":"National Academy of Sciences","issue":"28","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2009,7,14]]},"abstract":"<jats:p>\n                    Stem cells, their niches, and their relationship to cancer are under intense investigation. Because tumors and metastases acquire self-renewing capacity, mechanisms for their establishment may involve cell\u2013cell interactions similar to those between stem cells and stem cell niches. On the basis of our studies in\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    , we introduce the concept of a \u201clatent niche\u201d as a differentiated cell type that does not normally contact stem cells nor act as a niche but that can, under certain conditions, promote the ectopic self-renewal, proliferation, or survival of competent cells that it inappropriately contacts. Here, we show that ectopic germ-line stem cell proliferation in\n                    <jats:italic>C. elegans<\/jats:italic>\n                    is driven by a latent niche mechanism and that the molecular basis for this mechanism is inappropriate Notch activation. Furthermore, we show that continuous Notch signaling is required to maintain ectopic germ-line proliferation. We highlight the latent niche concept by distinguishing it from a normal stem cell niche, a premetastatic niche and an ectopic niche. One of the important distinguishing features of this mechanism for tumor initiation is that it could operate in the absence of genetic changes to the tumor cell or the tumor-promoting cell. We propose that a latent niche mechanism may underlie tumorigenesis and metastasis in humans.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0903768106","type":"journal-article","created":{"date-parts":[[2009,6,29]],"date-time":"2009-06-29T21:42:29Z","timestamp":1246311749000},"page":"11617-11622","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":81,"title":["A \u201clatent niche\u201d mechanism for tumor initiation"],"prefix":"10.1073","volume":"106","author":[{"given":"Marie","family":"McGovern","sequence":"first","affiliation":[{"name":"Developmental Genetics Program, Helen and Martin Kimmel Center for Stem Cell Biology, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, NY 10016;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roumen","family":"Voutev","sequence":"additional","affiliation":[{"name":"Developmental Genetics Program, Helen and Martin Kimmel Center for Stem Cell Biology, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, NY 10016;"},{"name":"Department of Biology, New York University, 100 Washington Square East, New York, NY 10003; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Maciejowski","sequence":"additional","affiliation":[{"name":"Department of Biology, New York University, 100 Washington Square East, New York, NY 10003; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann K.","family":"Corsi","sequence":"additional","affiliation":[{"name":"Department of Biology, The Catholic University of America, Washington, DC 20064"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Jane Albert","family":"Hubbard","sequence":"additional","affiliation":[{"name":"Developmental Genetics Program, Helen and Martin Kimmel Center for Stem Cell Biology, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, NY 10016;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2009,7,14]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21335"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.23.090506.123326"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(06)76006-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.112.1.231"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.120.10.2913"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.034603"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.4.925"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(81)90284-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.05.015"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1121908"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90060-R"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/139.2.579"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/163.1.115"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00005-8"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01002"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.06.009"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.06.011"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.05.024"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.107.070987"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00203-3"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(04)00021-8"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.12.021"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.229"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.16.1935"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9356"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/139.2.607"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0293"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.5.1011"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00916"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.12.009"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04186"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.003392"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06188"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0830856100"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1097676"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1161621"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.09.009"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)49915-0"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.108.090274"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2007.01.005"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/77.1.71"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01278"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.2505604"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.6.1791"},{"key":"e_1_3_3_45_2","first-page":"1","article-title":"Transcriptional regulation","volume":"2005","author":"Okkema PG","year":"2005","unstructured":"PG Okkema, M Krause, Transcriptional regulation. 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