{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:03:53Z","timestamp":1792886633099,"version":"4.5.0"},"reference-count":37,"publisher":"National Academy of Sciences","issue":"38","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2009,9,22]]},"abstract":"<jats:p>\n                    Renal excretion of water and major electrolytes exhibits a significant circadian rhythm. This functional periodicity is believed to result, at least in part, from circadian changes in secretion\/reabsorption capacities of the distal nephron and collecting ducts. Here, we studied the molecular mechanisms underlying circadian rhythms in the distal nephron segments, i.e., distal convoluted tubule (DCT) and connecting tubule (CNT) and the cortical collecting duct (CCD). Temporal expression analysis performed on microdissected mouse DCT\/CNT or CCD revealed a marked circadian rhythmicity in the expression of a large number of genes crucially involved in various homeostatic functions of the kidney. This analysis also revealed that both DCT\/CNT and CCD possess an intrinsic circadian timing system characterized by robust oscillations in the expression of circadian core clock genes (\n                    <jats:italic>clock<\/jats:italic>\n                    ,\n                    <jats:italic>bma11<\/jats:italic>\n                    ,\n                    <jats:italic>npas2<\/jats:italic>\n                    ,\n                    <jats:italic>per<\/jats:italic>\n                    ,\n                    <jats:italic>cry<\/jats:italic>\n                    ,\n                    <jats:italic>nr1d1<\/jats:italic>\n                    ) and clock-controlled Par bZip transcriptional factors\n                    <jats:italic>dbp<\/jats:italic>\n                    ,\n                    <jats:italic>hlf<\/jats:italic>\n                    , and\n                    <jats:italic>tef<\/jats:italic>\n                    . The\n                    <jats:italic>clock<\/jats:italic>\n                    knockout mice or mice devoid of\n                    <jats:italic>dbp<\/jats:italic>\n                    \/\n                    <jats:italic>hlf<\/jats:italic>\n                    \/\n                    <jats:italic>tef<\/jats:italic>\n                    (triple knockout) exhibit significant changes in renal expression of several key regulators of water or sodium balance (vasopressin V2 receptor, aquaporin-2, aquaporin-4, \u03b1ENaC). Functionally, the loss of\n                    <jats:italic>clock<\/jats:italic>\n                    leads to a complex phenotype characterized by partial diabetes insipidus, dysregulation of sodium excretion rhythms, and a significant decrease in blood pressure. Collectively, this study uncovers a major role of molecular clock in renal function.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0904890106","type":"journal-article","created":{"date-parts":[[2009,9,9]],"date-time":"2009-09-09T20:46:55Z","timestamp":1252529215000},"page":"16523-16528","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":259,"title":["Molecular clock is involved in predictive circadian adjustment of renal function"],"prefix":"10.1073","volume":"106","author":[{"given":"Annie Mercier","family":"Zuber","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Lausanne, 1005 Lausanne, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Centeno","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Lausanne, 1005 Lausanne, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Pradervand","sequence":"additional","affiliation":[{"name":"DNA Array Facility, University of Lausanne, 1015 Lausanne, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Nikolaeva","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Lausanne, 1005 Lausanne, Switzerland;"},{"name":"Institute of Evolutionary Physiology and Biochemistry, 194223 St-Petersburg, Russia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Maquelin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Lausanne, 1005 Lausanne, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9onard","family":"Cardinaux","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Lausanne, 1005 Lausanne, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Bonny","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Lausanne, 1005 Lausanne, Switzerland;"},{"name":"Service of Nephrology, Lausanne University Hospital, 1005 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitri","family":"Firsov","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Lausanne, 1005 Lausanne, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2009,9,22]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/0748730406293889"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0748730403018003007"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.183500"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.291.5503.490"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature744"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-11-r247"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00722-5"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050034"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806717105"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014218"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(80)90498-1"},{"key":"e_1_3_3_12_2","first-page":"18","article-title":"Intrinsic diurnal rhythm in urinary electrolyte output","volume":"115","author":"Mills JN","year":"1951","unstructured":"JN Mills, SW Stanbury, Intrinsic diurnal rhythm in urinary electrolyte output. J Physiol 115, 18\u201319 (1951).","journal-title":"J Physiol"},{"key":"e_1_3_3_13_2","first-page":"F128","article-title":"Renal electrolyte circadian rhythms: Independence from feeding and activity patterns","volume":"232","author":"Moore-Ede MC","year":"1977","unstructured":"MC Moore-Ede, JA Herd, Renal electrolyte circadian rhythms: Independence from feeding and activity patterns. Am J Physiol 232, F128\u2013F135 (1977).","journal-title":"Am J Physiol"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1969.26.6.720"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(70)90336-X"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(82)90612-9"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.105510"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2007.07.007"},{"key":"e_1_3_3_19_2","first-page":"487","article-title":"Abnormalities in circadian patterns of bone resorption and renal calcium conservation in type I osteoporosis","volume":"74","author":"Eastell R","year":"1992","unstructured":"R Eastell, et al., Abnormalities in circadian patterns of bone resorption and renal calcium conservation in type I osteoporosis. J Clin Endocrinol Metab 74, 487\u2013494 (1992).","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-004-1767-7"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.08.028"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.04.054"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.0590051873.x"},{"key":"e_1_3_3_24_2","first-page":"1330","article-title":"Circadian rhythm of glomerular filtration rate in patients after kidney transplantation","volume":"9","author":"Buijsen JG","year":"1994","unstructured":"JG Buijsen, et al., Circadian rhythm of glomerular filtration rate in patients after kidney transplantation. Nephrol Dial Transplant 9, 1330\u20131333 (1994).","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00217.2002"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00201.2007"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.03.041"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.04.015"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806962106"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80959-9"},{"key":"e_1_3_3_31_2","first-page":"R737","article-title":"Physiology of the circadian timing system: Predictive versus reactive homeostasis","volume":"250","author":"Moore-Ede MC","year":"1986","unstructured":"MC Moore-Ede, Physiology of the circadian timing system: Predictive versus reactive homeostasis. Am J Physiol 250, R737\u2013R752 (1986).","journal-title":"Am J Physiol"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02584033"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.2.185"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btg405"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/4.2.249"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2124"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780090710"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.0904890106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T17:10:32Z","timestamp":1653325832000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.0904890106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,22]]},"references-count":37,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2009,9,22]]}},"alternative-id":["10.1073\/pnas.0904890106"],"URL":"https:\/\/doi.org\/10.1073\/pnas.0904890106","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1168038.630147","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,22]]},"assertion":[{"value":"2009-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-09-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}