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In the adult brain, angiopoietin2 and the Notch ligand Dll4 activate neural precursors with opposing effects on the density of blood vessels. A model of Parkinson's disease was used to show that angiopoietin2 and Dll4 rescue injured dopamine neurons with motor behavioral improvement. A combination of growth factors with little impact on the vasculature retains the ability to stimulate neural precursors and protect dopamine neurons. The cellular and pharmacological basis of the neuroprotective effects achieved by these single treatments merits further analysis.<\/jats:p>","DOI":"10.1073\/pnas.0905125106","type":"journal-article","created":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T21:36:29Z","timestamp":1248384989000},"page":"13570-13575","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":81,"title":["Targeting neural precursors in the adult brain rescues injured dopamine neurons"],"prefix":"10.1073","volume":"106","author":[{"given":"Andreas","family":"Androutsellis-Theotokis","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Rueger","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deric 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