{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:47:56Z","timestamp":1790416076933,"version":"4.1.0"},"reference-count":36,"publisher":"National Academy of Sciences","issue":"42","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2009,10,20]]},"abstract":"<jats:p>\n                    Although Epstein-Barr virus (EBV) is linked to Burkitt's lymphoma (BL), the role of the virus in lymphomagenesis is unclear. LMP2A, encoded by EBV, can be detected in BL biopsies and has prosurvival functions. We generated mice expressing MYC and LMP2A in B cells. LMP2A\/\u03bb-\n                    <jats:italic>MYC<\/jats:italic>\n                    mice show greatly accelerated tumor onset. Similar to previous work, we found p53 mutations in \u03bb-\n                    <jats:italic>MYC<\/jats:italic>\n                    tumors; however, we detected no mutations in the rapidly arising LMP2A\/\u03bb-\n                    <jats:italic>MYC<\/jats:italic>\n                    tumors. We further demonstrate that the p53 pathway is functionally intact in LMP2A\/\u03bb-\n                    <jats:italic>MYC<\/jats:italic>\n                    tumors, which have increased levels of PUMA and sensitivity to p53 activation by Nutlin. This work shows that LMP2A can permit tumorigenesis in the presence of an intact p53 pathway, identifying an important contribution of EBV to BL.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0907994106","type":"journal-article","created":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T22:11:39Z","timestamp":1254953499000},"page":"17945-17950","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":40,"title":["Epstein-Barr virus LMP2A bypasses p53 inactivation in a MYC model of lymphomagenesis"],"prefix":"10.1073","volume":"106","author":[{"given":"Kathryn T.","family":"Bieging","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra C.","family":"Amick","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Longnecker","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2009,10,20]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)91524-7"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2007.1.277"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7824"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7837"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc904"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.12.5413"},{"key":"e_1_3_3_7_2","first-page":"4273","article-title":"The pattern of p53 mutations in Burkitt's lymphoma differs from that of solid tumors","volume":"52","author":"Bhatia KG","year":"1992","unstructured":"KG Bhatia, MI Gutierrez, K Huppi, D Siwarski, IT Magrath, The pattern of p53 mutations in Burkitt's lymphoma differs from that of solid tumors. 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